Sepsis is a life-threatening disorder disease defined as infection-induced dysregulated
immune responses and multiple organ dysfunction. The imbalance between …

The extracellular nucleoside adenosine reduces tissue inflammation and is generated by
irreversible dephosphorylation of adenosine monophosphate (AMP) mediated by the …

Adenosine receptors (ARs) are widely acknowledged pharmacological targets yet are still
underutilized in clinical practice. Their ubiquitous distribution in almost all cells and tissues …

Sepsis is described as a life-threatening organ dysfunction and a heterogeneous syndrome
that is a leading cause of morbidity and mortality in intensive care settings. Severe sepsis …

Sepsis is a dysregulation of the immune response to pathogens and has high morbidity and
mortality worldwide. However, the unclear mapping and course of dysregulated immune …

Long-term protective immunity to infectious disease depends on cell-mediated and humoral
immune responses. Induction of a strong humoral response relies on efficient B cell …

Sepsis-induced cardiomyopathy (SICM) has a poor prognosis, with no effective therapeutic
strategy currently. This study aimed to explore the mechanism underlying SICM and …

The advent of cancer immunotherapy based on PD-1 and CTLA-4 immune checkpoint
blockade (ICB) has revolutionized cancer treatment. However, many cancers do not respond …

Sepsis is a life-threatening syndrome caused by anomalous host response to infection. The
pathogenesis of sepsis is complex, and immune dysfunction is the central link in its …

Infectious diseases are caused by the invasion of pathogenic microorganisms such as fungi,
bacteria, viruses, and parasites. After infection, disease progression relies on the complex …