Molecular mechanisms and future implications of VEGF/VEGFR in cancer therapy

SA Patel, MB Nilsson, X Le, T Cascone, RK Jain… - Clinical Cancer …, 2023 - AACR
Angiogenesis, the sprouting of new blood vessels from existing vessels, is one of six known
mechanisms employed by solid tumors to recruit blood vessels necessary for their initiation …

Tumor endothelial cells accelerate tumor metastasis

N Maishi, K Hida - Cancer science, 2017 - Wiley Online Library
Tumor metastasis is the main cause of cancer‐related death. Understanding the molecular
mechanisms underlying tumor metastasis is crucial to control this fatal disease. Several …

Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer

CG Willett, Y Boucher, E Di Tomaso, DG Duda… - Nature medicine, 2004 - nature.com
The effects of vascular endothelial growth factor (VEGF) blockade on the vascular biology of
human tumors are not known. Here we show here that a single infusion of the VEGF-specific …

Human endothelial progenitor cells

MC Yoder - Cold Spring Harbor perspectives in …, 2012 - perspectivesinmedicine.cshlp.org
Human endothelial progenitor cells (EPCs) have been generally defined as circulating cells
that express a variety of cell surface markers similar to those expressed by vascular …

Endothelial progenitor cells: identity defined?

F Timmermans, J Plum, MC Yöder… - Journal of cellular …, 2009 - Wiley Online Library
• Introduction• The proof‐of‐concept in vivo: the cell, the read‐out and the animal model‐The
CEPC: Still a putative cell‐Do CEPCs play an essential role in vascular (patho) physiology …

Detection of circulating tumor cells as a prognostic factor in patients undergoing radical surgery for non‐small‐cell lung carcinoma: comparison of the efficacy of the …

V Hofman, MI Ilie, E Long, E Selva… - … journal of cancer, 2011 - Wiley Online Library
Abstract Comparison of the efficacy of different enrichment methods for detection of
circulating tumor cells (CTCs) before radical surgery is lacking in non‐small‐cell lung …

Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?

S Rafii, D Lyden, R Benezra, K Hattori… - Nature Reviews …, 2002 - nature.com
Tumours recruit neighbouring blood vessels and vascular endothelial cells to support their
own blood supply. Recent evidence has indicated, however, that tumours are also capable …

Preoperative circulating tumor cell detection using the isolation by size of epithelial tumor cell method for patients with lung cancer is a new prognostic biomarker

V Hofman, C Bonnetaud, MI Ilie, P Vielh… - Clinical cancer …, 2011 - AACR
Purpose: Pathologic TNM staging is currently the best prognostic factor for non‐small cell
lung carcinoma (NSCLC). However, even in early-stage NSCLC, the recurrence rates after …

The multifaceted circulating endothelial cell in cancer: towards marker and target identification

F Bertolini, Y Shaked, P Mancuso, RS Kerbel - Nature Reviews Cancer, 2006 - nature.com
Increases in the number of circulating endothelial cells (CECs) and progenitors (CEPs) have
been reported in various pathological conditions including cancer. Preclinical studies have …

Maximum tolerable dose and low-dose metronomic chemotherapy have opposite effects on the mobilization and viability of circulating endothelial progenitor cells

F Bertolini, S Paul, P Mancuso, S Monestiroli, A Gobbi… - Cancer research, 2003 - AACR
There is growing evidence that vasculogenesis (progenitor cell-derived generation of new
blood vessels) is required for the growth of some neoplastic diseases. Here we show that …