Molecular mechanisms and future implications of VEGF/VEGFR in cancer therapy
Angiogenesis, the sprouting of new blood vessels from existing vessels, is one of six known
mechanisms employed by solid tumors to recruit blood vessels necessary for their initiation …
mechanisms employed by solid tumors to recruit blood vessels necessary for their initiation …
Tumor endothelial cells accelerate tumor metastasis
N Maishi, K Hida - Cancer science, 2017 - Wiley Online Library
Tumor metastasis is the main cause of cancer‐related death. Understanding the molecular
mechanisms underlying tumor metastasis is crucial to control this fatal disease. Several …
mechanisms underlying tumor metastasis is crucial to control this fatal disease. Several …
Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
CG Willett, Y Boucher, E Di Tomaso, DG Duda… - Nature medicine, 2004 - nature.com
The effects of vascular endothelial growth factor (VEGF) blockade on the vascular biology of
human tumors are not known. Here we show here that a single infusion of the VEGF-specific …
human tumors are not known. Here we show here that a single infusion of the VEGF-specific …
Human endothelial progenitor cells
MC Yoder - Cold Spring Harbor perspectives in …, 2012 - perspectivesinmedicine.cshlp.org
Human endothelial progenitor cells (EPCs) have been generally defined as circulating cells
that express a variety of cell surface markers similar to those expressed by vascular …
that express a variety of cell surface markers similar to those expressed by vascular …
Endothelial progenitor cells: identity defined?
F Timmermans, J Plum, MC Yöder… - Journal of cellular …, 2009 - Wiley Online Library
• Introduction• The proof‐of‐concept in vivo: the cell, the read‐out and the animal model‐The
CEPC: Still a putative cell‐Do CEPCs play an essential role in vascular (patho) physiology …
CEPC: Still a putative cell‐Do CEPCs play an essential role in vascular (patho) physiology …
Detection of circulating tumor cells as a prognostic factor in patients undergoing radical surgery for non‐small‐cell lung carcinoma: comparison of the efficacy of the …
V Hofman, MI Ilie, E Long, E Selva… - … journal of cancer, 2011 - Wiley Online Library
Abstract Comparison of the efficacy of different enrichment methods for detection of
circulating tumor cells (CTCs) before radical surgery is lacking in non‐small‐cell lung …
circulating tumor cells (CTCs) before radical surgery is lacking in non‐small‐cell lung …
Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?
Tumours recruit neighbouring blood vessels and vascular endothelial cells to support their
own blood supply. Recent evidence has indicated, however, that tumours are also capable …
own blood supply. Recent evidence has indicated, however, that tumours are also capable …
Preoperative circulating tumor cell detection using the isolation by size of epithelial tumor cell method for patients with lung cancer is a new prognostic biomarker
Purpose: Pathologic TNM staging is currently the best prognostic factor for non‐small cell
lung carcinoma (NSCLC). However, even in early-stage NSCLC, the recurrence rates after …
lung carcinoma (NSCLC). However, even in early-stage NSCLC, the recurrence rates after …
The multifaceted circulating endothelial cell in cancer: towards marker and target identification
Increases in the number of circulating endothelial cells (CECs) and progenitors (CEPs) have
been reported in various pathological conditions including cancer. Preclinical studies have …
been reported in various pathological conditions including cancer. Preclinical studies have …
Maximum tolerable dose and low-dose metronomic chemotherapy have opposite effects on the mobilization and viability of circulating endothelial progenitor cells
F Bertolini, S Paul, P Mancuso, S Monestiroli, A Gobbi… - Cancer research, 2003 - AACR
There is growing evidence that vasculogenesis (progenitor cell-derived generation of new
blood vessels) is required for the growth of some neoplastic diseases. Here we show that …
blood vessels) is required for the growth of some neoplastic diseases. Here we show that …