The identification of potential therapeutic agents for the treatment of epilepsy requires the
use of seizure models. Except for some early treatments, including bromides and …

Background Epilepsy is a common and debilitating consequence of traumatic brain injury
(TBI). Seizures contribute to progressive neurodegeneration and poor functional and …

Epilepsy has remained a significant social concern and financial burden globally. Current
therapeutic strategies are based primarily on neurocentric mechanisms that have not proven …

Onset of many forms of epilepsy occurs after an initial epileptogenic insult or as a result of an
identified genetic defect. Given that the precipitating insult is known, these epilepsies are, in …

In the last 30 years, over 20 new anti-seizure medicines (ASMs) have been introduced into
the market for the treatment of epilepsy using well-established preclinical seizure and …

Many experimental approaches require housing rodents in individual cages, including in
epilepsy research. However, rats and mice are social animals; and individual housing …

The pilocarpine animal model of status epilepticus is a well-established, clinically
translatable model that satisfies all of the criteria essential for an animal model of status …

Extensive activation of glial cells during a latent period has been well documented in various
animal models of epilepsy. However, it remains unclear whether activated glial cells …

Epilepsy is a serious neurological disorder characterized by abnormal, recurrent, and
synchronous discharges in the brain. Long-term recurrent seizure attacks can cause serious …

It is well established that epilepsy is associated with numerous neurobehavioral
comorbidities, with a bidirectional relationship; people with epilepsy have an increased …