Animal models of seizures and epilepsy: past, present, and future role for the discovery of antiseizure drugs
W Löscher - Neurochemical research, 2017 - Springer
The identification of potential therapeutic agents for the treatment of epilepsy requires the
use of seizure models. Except for some early treatments, including bromides and …
use of seizure models. Except for some early treatments, including bromides and …
[HTML][HTML] Inflammation in epileptogenesis after traumatic brain injury
Background Epilepsy is a common and debilitating consequence of traumatic brain injury
(TBI). Seizures contribute to progressive neurodegeneration and poor functional and …
(TBI). Seizures contribute to progressive neurodegeneration and poor functional and …
Microglia–neuron communication in epilepsy
Epilepsy has remained a significant social concern and financial burden globally. Current
therapeutic strategies are based primarily on neurocentric mechanisms that have not proven …
therapeutic strategies are based primarily on neurocentric mechanisms that have not proven …
[HTML][HTML] Identification of clinically relevant biomarkers of epileptogenesis—a strategic roadmap
M Simonato, DV Agoston, A Brooks-Kayal… - Nature Reviews …, 2021 - nature.com
Onset of many forms of epilepsy occurs after an initial epileptogenic insult or as a result of an
identified genetic defect. Given that the precipitating insult is known, these epilepsies are, in …
identified genetic defect. Given that the precipitating insult is known, these epilepsies are, in …
[HTML][HTML] Animal models of drug-resistant epilepsy as tools for deciphering the cellular and molecular mechanisms of pharmacoresistance and discovering more …
W Löscher, HS White - Cells, 2023 - mdpi.com
In the last 30 years, over 20 new anti-seizure medicines (ASMs) have been introduced into
the market for the treatment of epilepsy using well-established preclinical seizure and …
the market for the treatment of epilepsy using well-established preclinical seizure and …
Effects of single cage housing on stress, cognitive, and seizure parameters in the rat and mouse pilocarpine models of epilepsy
H Manouze, A Ghestem, V Poillerat, M Bennis… - Eneuro, 2019 - eneuro.org
Many experimental approaches require housing rodents in individual cages, including in
epilepsy research. However, rats and mice are social animals; and individual housing …
epilepsy research. However, rats and mice are social animals; and individual housing …
[HTML][HTML] The evolution of the pilocarpine animal model of status epilepticus
IIA Juvale, ATC Has - Heliyon, 2020 - cell.com
The pilocarpine animal model of status epilepticus is a well-established, clinically
translatable model that satisfies all of the criteria essential for an animal model of status …
translatable model that satisfies all of the criteria essential for an animal model of status …
[HTML][HTML] Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus
F Sano, E Shigetomi, Y Shinozaki, H Tsuzukiyama… - JCI insight, 2021 - ncbi.nlm.nih.gov
Extensive activation of glial cells during a latent period has been well documented in various
animal models of epilepsy. However, it remains unclear whether activated glial cells …
animal models of epilepsy. However, it remains unclear whether activated glial cells …
[HTML][HTML] Animal models of epilepsy: a phenotype-oriented review
Epilepsy is a serious neurological disorder characterized by abnormal, recurrent, and
synchronous discharges in the brain. Long-term recurrent seizure attacks can cause serious …
synchronous discharges in the brain. Long-term recurrent seizure attacks can cause serious …
Epilepsy and its neurobehavioral comorbidities: insights gained from animal models
W Löscher, CE Stafstrom - Epilepsia, 2023 - Wiley Online Library
It is well established that epilepsy is associated with numerous neurobehavioral
comorbidities, with a bidirectional relationship; people with epilepsy have an increased …
comorbidities, with a bidirectional relationship; people with epilepsy have an increased …