Predictive performance of physiologically based pharmacokinetic modelling of beta-lactam antibiotic concentrations in adipose, bone, and muscle tissues
PJ De Sutter, P De Cock, TN Johnson, H Musther… - Drug Metabolism and …, 2023 - ASPET
Physiologically based pharmacokinetic (PBPK) models consist of compartments
representing different tissues. As most models are only verified based on plasma …
representing different tissues. As most models are only verified based on plasma …
Simultaneous determination of ceftazidime and avibactam in human plasma and cerebrospinal fluid by high-performance liquid chromatography–tandem mass …
Q Wang, Y Zheng, L Liu, P Ji, W Jiang, J Zhao… - Analytical …, 2023 - Taylor & Francis
A method is reported for the simultaneous determination of ceftazidime and avibactam in
human plasma and cerebrospinal fluid utilizing high-performance liquid chromatography …
human plasma and cerebrospinal fluid utilizing high-performance liquid chromatography …
Patients with Obesity Should be Recognised as a Special Patient Population During Drug Development of Antibacterial and Antifungal Agents; A Call to Action
KP van Rhee, CAJ Knibbe, PD van der Linden… - Clinical …, 2024 - Springer
Individuals with obesity are at increased risk of developing infectious diseases. Timely
administration of an effective dose of an antimicrobial agent is paramount to safeguard …
administration of an effective dose of an antimicrobial agent is paramount to safeguard …
Effect of Different Piperacillin-Tazobactam Dosage Regimens on Synergy of the Combination with Tobramycin against Pseudomonas aeruginosa for the …
We evaluated piperacillin-tazobactam and tobramycin regimens against Pseudomonas
aeruginosa isolates from critically ill patients. Static-concentration time-kill studies (SCTK) …
aeruginosa isolates from critically ill patients. Static-concentration time-kill studies (SCTK) …