Background & Aims We performed a systematic review and meta-analysis to
comprehensively estimate adenoma miss rate (AMR) and advanced AMR (AAMR) and …

In addition to the adenoma to carcinoma sequence, colorectal carcinogenesis can occur via
the serrated pathway. Studies have focused on clarification of categories and molecular …

Sporadic colorectal cancer (CRC) is a somatic genetic disease in which pathogenesis is
influenced by the local colonic environment and the patient's genetic background …

Background & Aims Serrated polyps (SPs) and conventional adenomas are precursor
lesions for colorectal cancer (CRC), but they are believed to arise via distinct pathways. We …

Introduction Advances in our understanding of the molecular genetics and epigenetics of
colorectal cancer have led to novel insights into the pathogenesis of this common cancer …

Objective Sessile serrated adenomas (SSAs) are the precursors of at least 15% of colorectal
carcinomas, but their biology is incompletely understood. We performed a …

Colorectal cancer (CRC) is considered a heterogeneous disease, both regarding
pathogenesis and clinical behaviour. Four decades ago, the adenoma–carcinoma pathway …

Our understanding of serrated colorectal polyps has increased dramatically over the past
two decades and has led to a modern classification scheme for these lesions. Sessile …

The traditional serrated adenoma is the least common colorectal serrated polyp. The
clinicopathological features and molecular drivers of these polyps require further …

The serrated pathway (SP) can be viewed as two parallel, but partially overlapping, arrays of
colorectal precursor lesions, and their respective endpoint carcinomas, that are distinct from …