Myeloid cells are the most abundant immune components of the tumour microenvironment,
where they have a variety of functions, ranging from immunosuppressive to …

Neutrophils are critical to innate immunity, including host defense against bacterial and
fungal infections. They achieve their host defense role by phagocytosing pathogens …

Decades of research have characterized diverse immune cells surveilling the CNS. More
recently, the discovery of osseous channels (so-called 'skull channels') connecting the …

Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant
expansion and proliferation of macrophages around injured sensory neurons in dorsal root …

Novel experimental approaches such as fate-mapping and single-cell analysis have brought
fresh insight into monocyte development and function over the past decade and helped …

Dendritic cells (DCs) develop in the bone marrow from haematopoietic progenitors that have
numerous shared characteristics between mice and humans. Human counterparts of mouse …

The tuberculosis vaccine bacillus Calmette-Guérin (BCG) protects against some
heterologous infections, probably via induction of non-specific innate immune memory in …

Dendritic cells (DCs) possess the ability to integrate information about their environment and
communicate it to other leukocytes, shaping adaptive and innate immunity. Over the years, a …

INTRODUCTION During tissue turnover, stem and progenitor cells differentiate to produce
mature cell types. To understand and ultimately control differentiation, it is important to …

Self-renewal and differentiation are tightly controlled to maintain haematopoietic stem cell
(HSC) homeostasis in the adult bone marrow,. During fetal development, expansion of …