Tumor vascularization occurs through several distinct biological processes, which not only
vary between tumor type and anatomic location, but also occur simultaneously within the …

Apelin is an endogenous peptide identified as a ligand of the G protein-coupled receptor
APJ. Apelin belongs to the family of adipokines, which are bioactive mediators released by …

Apelin, a regulatory peptide, is a ligand of the APJ receptor that belongs to the G protein-
coupled receptor family. Apelin and APJ are widely distributed in the body and play potential …

Apelin is an endogenous peptide, which is expressed in a vast board of organs such as the
brain, placenta, heart, lungs, kidneys, pancreas, testis, prostate and adipose tissues. The …

Background and Aims Apelin (APLN) is the endogenous ligand of its G protein–coupled
receptor, apelin receptor (APJ). APLN serum levels are increased in human liver diseases …

Osteosarcoma is a highly mortal bone tumor, with a high metastatic potential, promoted in
part by the enzyme procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 (PLOD2). Increasing …

Cholangiocarcinoma (CCA) is aggressive and has poor clinical outcomes because of
typically delayed diagnosis and a lack of effective non-surgical therapeutic options. Recent …

Cancer is a disease that seriously endangers human health and is mainly characterized by
a high metastasis rate, a high recurrence rate, and a high mortality rate. The treatment of …

The apelinergic system is widely expressed and acts through autocrine and paracrine
signaling to exert protective effects, including vasodilatory, metabolic, and inotropic effects …

Alzheimer's disease (AD) is the most common type of dementia. Currently, more than 50
million people live with dementia worldwide, and this number is expected to increase. Some …