Medicinal plants with concomitant anti-diabetic and anti-hypertensive effects as potential sources of dual acting therapies against diabetes and hypertension: A review

CI Chukwuma, MG Matsabisa, MA Ibrahim… - Journal of …, 2019 - Elsevier
Ethnopharmacological relevance Diabetes and hypertension are pathophysiologically
related diseases that co-exist with a wider complex of metabolic diseases having similar set …

Biological and pharmacological potential of xylitol: a molecular insight of unique metabolism

V Ahuja, M Macho, D Ewe, M Singh, S Saha, K Saurav - Foods, 2020 - mdpi.com
Xylitol is a white crystalline, amorphous sugar alcohol and low-calorie sweetener. Xylitol
prevents demineralization of teeth and bones, otitis media infection, respiratory tract …

Hypoglycemic Potential of Aqueous Extract of Moringa oleifera Leaf and In Vivo GC-MS Metabolomics

W Khan, R Parveen, K Chester, S Parveen… - Frontiers in …, 2017 - frontiersin.org
Moringa oleifera Lam.(family; Moringaceae), commonly known as drumstick, have been
used for centuries as a part of the Ayurvedic system for several diseases without having any …

[HTML][HTML] Suitability of sugar alcohols as antidiabetic supplements: A review

NZ Msomi, OL Erukainure, MS Islam - Journal of food and drug …, 2021 - ncbi.nlm.nih.gov
The major goals in the management of diabetes are to maintain optimum control of high
blood glucose level or hyperglycemia. Dietary modification is one of the most recommended …

Metabolic effects of the natural sweeteners xylitol and erythritol: A comprehensive review

BK Wölnerhanssen, AC Meyer-Gerspach… - Critical reviews in …, 2020 - Taylor & Francis
Xylitol and erythritol are widely used in a variety of food and oral care products as sugar
substitutes. Although a number of studies have been conducted on the health benefits of …

Erythritol reduces small intestinal glucose absorption, increases muscle glucose uptake, improves glucose metabolic enzymes activities and increases expression of …

CI Chukwuma, R Mopuri, S Nagiah… - European journal of …, 2018 - Springer
Purpose Studies have reported that erythritol, a low or non-glycemic sugar alcohol
possesses anti-hyperglycemic and anti-diabetic potentials but the underlying mode of …

Effect of the natural sweetener xylitol on gut hormone secretion and gastric emptying in humans: a pilot dose-ranging study

AC Meyer-Gerspach, J Drewe, W Verbeure, CW Roux… - Nutrients, 2021 - mdpi.com
Sugar consumption is associated with a whole range of negative health effects and should
be reduced and the natural sweetener xylitol might be helpful in achieving this goal. The …

Vernonia Amygdalina Del. stimulated glucose uptake in brain tissues enhances antioxidative activities; and modulates functional chemistry and dysregulated …

OL Erukainure, OA Oyebode, CU Ibeji… - Metabolic brain …, 2019 - Springer
Brain glucose uptake is usually reduced in type 2 diabetes owing to downregulation of brain
glucose transporters. The ability of Vernonia amygdalina to stimulate glucose uptake as well …

[HTML][HTML] Azadirachta indica inhibits key enzyme linked to type 2 diabetes in vitro, abates oxidative hepatic injury and enhances muscle glucose uptake ex vivo

O Sanni, OL Erukainure, CI Chukwuma… - Biomedicine & …, 2019 - Elsevier
The progression of secondary complications in type 2 diabetes (T2D) has been linked to
oxidative stress caused by hyperglycemia. Therefore, the control of hyperglycemia is the …

Type 2 diabetes induced oxidative brain injury involves altered cerebellar neuronal integrity and elemental distribution, and exacerbated Nrf2 expression: therapeutic …

OL Erukainure, OM Ijomone, O Sanni, M Aschner… - Metabolic brain …, 2019 - Springer
Neurodegenerative diseases, such as Alzheimer's disease have been recognized as one of
the microvascular complications of type 2 diabetes (T2D). In this study, the effect of T2D on …