Calcium diffusion in the thin 100 nm layer located between the plasma membrane and
docked vesicles in the pre-synaptic terminal of neuronal cells mediates vesicular fusion and …

Serotonergic neurons of the dorsal raphe nucleus, with their extensive innervation of limbic
and higher brain regions and interactions with the endocrine system have important …

We study local calcium dynamics leading to a vesicle fusion in a stochastic, and spatially
explicit, biophysical model of the CA3-CA1 presynaptic bouton. The kinetic model for vesicle …

The timing and probability of synaptic vesicle fusion from presynaptic terminals is governed
by the distance between voltage-gated Ca2+ channels (VGCCs) and Ca2+ sensors for …

Synaptic transmission between neurons is governed by a cascade of stochastic calcium ion
reaction–diffusion events within nerve terminals leading to vesicular release of …

Although the CA3–CA1 synapse is critically important for learning and memory,
experimental limitations have to date prevented direct determination of the structural …

The biological processes in elongated organelles of living cells are often regulated by
molecular motor transport. We determined spatial distributions of motors in such organelles …

Several models of Gastric Emptying (GE) have been employed in the past to represent the
rate of delivery of stomach contents to the duodenum and jejunum. These models have all …

The active zone of presynaptic nerve terminals organizes the neurotransmitter release
machinery, thereby enabling fast Ca2+‐triggered synaptic vesicle exocytosis. BK‐channels …

Binding of molecules, ions or proteins to small target sites is a generic step of cell activation.
This process relies on rare stochastic events where a particle located in a large bulk has to …