Genomics-based precision medicine has revolutionized oncology but also has inherent
limitations. Functional precision oncology is emerging as a complementary approach that …

High-grade serous ovarian cancer (HGSOC) is notoriously known as the “silent killer” of post-
menopausal women as it has an insidious progression and is the deadliest gynaecological …

Despite many improvements in ovarian cancer diagnosis and treatment, until now,
conventional chemotherapy and new biological drugs have not been shown to cure the …

Functional assays on intact tumor biopsies can complement genomics-based approaches
for precision oncology, drug testing, and organs-on-chips cancer disease models by …

Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. Among the key
challenges in developing effective therapeutics is the poor translation of preclinical models …

The poor prognosis of pancreatic ductal adenocarcinoma (PDAC) is attributed to the highly
fibrotic stroma and complex multi-cellular microenvironment that is difficult to fully …

Precision medicine approaches that inform clinical management of individuals with cancer
are progressively advancing. Patient-derived explants (PDEs) provide a patient-proximal ex …

Ovarian carcinoma (OvC) remains a major therapeutic challenge due to its propensity to
develop resistance after an initial response to chemotherapy. Interactions of tumour cells …

Hyaluronic acid (HA) is a major component of the extracellular matrix, providing essential
mechanical scaffolding for cells and, at the same time, mediating essential biochemical …

We have recently shown that the extracellular matrix molecule hyaluronan (HA) plays a role
in the development of ovarian cancer chemoresistance. This present study determined if HA …