The most frequent adult-type primary CNS tumours are diffuse gliomas, but a large variety of
rarer CNS tumour types exists. The classification of these tumours is increasingly based on …

Background Isocitrate dehydrogenase (IDH)–mutant grade 2 gliomas are malignant brain
tumors that cause considerable disability and premature death. Vorasidenib, an oral brain …

Abstract Purpose of Review Molecular profiling enables the evaluation of genetic alterations
for the diagnosis and classification of gliomas and the selection of appropriate therapies …

Purpose: Isocitrate dehydrogenase–mutant (IDH-mt) gliomas are incurable primary brain
tumors characterized by a slow-growing phase over several years followed by a rapid …

Simple Summary IDH-mutant low-grade gliomas (LGG) are slow-growing glial cell-derived
tumors of the central nervous system (CNS) that predominantly manifest in young adults and …

Advances in molecular profiling have led to improved understanding of glioma
heterogeneity. Results have been used to inform diagnostic classification and targeted …

Glioma is one of the most common types of brain tumors, and its high recurrence and
mortality rates threaten human health. In 2008, the frequent isocitrate dehydrogenase 1 …

The ability to control enzyme cascades entrapped in a nanoporous electrode material (the
“Electrochemical Leaf”, e‐Leaf) has been exploited to gain detailed kinetic insight into the …

Highlights•Cancer cell-derived D-and L-2HG regulate antitumor immunity.•Both 2HG
enantiomers physiologically accumulate in immune cells.•D-2HG and L-2HG should not be …

Abstract" Oncometabolite" 2-hydroxyglutarate (2-HG) is an aberrant metabolite found in
tumor cells, exerting a pivotal influence on tumor progression. Recent studies have unveiled …