Dissecting the mechanism of Yuzhi Zhixue granule on ovulatory dysfunctional uterine bleeding by network pharmacology and molecular docking

J Li, H Luo, X Liu, J Zhang, W Zhou, S Guo, X Chen… - Chinese Medicine, 2020 - Springer
Abstract Background Yuzhi Zhixue Granule (YZG) is a traditional Chinese patent medicine
for treating excessive menstrual flow caused by ovulatory dysfunctional uterine bleeding …

Janus kinase inhibitors modify the fatty acid profile of extracellular vesicles and modulate the immune response

AMD Zapata, K Álvarez, GV Duque, J Palacio… - Heliyon, 2024 - cell.com
Background Janus kinase inhibitors (jakinibs) are immunomodulators used for treating
malignancies, autoimmune diseases, and immunodeficiencies. However, they induce …

Reprogramming Megakaryocytes for Controlled Release of Platelet-like Particles Carrying a Single-Chain Thromboxane A2 Receptor-G-Protein Complex with …

R Lu, Y Li, A Xu, B King, KH Ruan - Cells, 2023 - mdpi.com
In this study, we reported that novel single-chain fusion proteins linking thromboxane A2
(TXA2) receptor (TP) to a selected G-protein α-subunit q (SC-TP-Gαq) or to α-subunit s (SC …

Anti-inflammatory effect of phytoncide in an animal model of gastrointestinal inflammation

A Memon, BY Kim, S Kim, Y Pyao, YG Lee, SC Kang… - Molecules, 2021 - mdpi.com
Background: Phytoncide is known to have antimicrobial and anti-inflammatory properties.
Purpose: This study was carried out to confirm the anti-inflammatory activity of two types of …

Parsing the Q-Markers of Baoyin Jian to Treat Abnormal Uterine Bleeding by High-Throughput Chinmedomics Strategy

Q Li, J Ren, L Yang, H Sun, X Zhang, G Yan, Y Han… - Pharmaceuticals, 2023 - mdpi.com
Abnormal uterine bleeding (AUB) is a common and frequently occurring disease in
gynecology, seriously threatening women's health. Baoyin Jian (BYJ) is a classical …

Reprogramming Megakaryocyte Gene Expression to Release Platelet-Like Particles with Opposite Biological Activities: Carrying Single-Chain Thromboxane A2 …

R Lu, Y Li, A Xu, B King, KH Ruan - 2023 - preprints.org
In this study, we reported that novel single-chain fusion-proteins linked thromboxane A2
(TXA2) receptor (TP) to a selected G-protein α-subunit q (SC-TP-Gαq), or s (SC-TP-Gαs) …

Caractérisation de nouvelles molécules vasorelaxantes: études chimico-pharmacologique de Carissa edulis, une espèce médicinale de la pharmacopée béninoise

UM Houngue - 2021 - theses.hal.science
Les maladies cardiovasculaires représentent la première cause de mortalité dans le monde
et leur incidence est associée à plusieurs facteurs de risque majeurs dont l'hypertension …

Redirecting Thromboxane A2 and Prostacyclin Biosyntheses from Thrombotic to Antithrombotic Property by an Enzymelink

DT Ruan, R Lu, KH Ruan - Future Medicinal Chemistry, 2021 - Taylor & Francis
This editorial provides commentary on an innovative 'Enzymelink'technology for regulation
of endogenous lipid metabolites to benefit patients with heart disease. The biosynthesis of …