Preclinical studies of the T cell growth factor activity of IL-2 resulted in this cytokine
becoming the first immunotherapy to be approved nearly 30 years ago by the US Food and …

Naive T cells have long been regarded as a developmentally synchronized and fairly
homogeneous and quiescent cell population, the size of which depends on age, thymic …

Extensive, large-scale single-cell profiling of healthy human blood at different ages is one of
the critical pending tasks required to establish a framework for the systematic understanding …

Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system
underpinned by partially understood genetic risk factors and environmental triggers and …

In studies of immune aging, naive T cells frequently take center stage. Describing the
complexity of the human naive T cell repertoire remains a daunting task; however, emerging …

The adaptive immune system has the enormous challenge to protect the host through the
generation and differentiation of pathogen‐specific short‐lived effector T cells while in …

Immune aging combines cellular defects in adaptive immunity with the activation of
pathways causing a low-inflammatory state. Here we examined the influence of age on the …

Susceptibility to multiple autoimmune diseases is associated with common gene
polymorphisms influencing IL-2 signaling and T reg function, making T reg-specific …

The defense against infectious diseases, either through natural immunity or after
vaccinations, relies on the generation and maintenance of protective T cell memory. Naïve T …

Regulatory T (Treg) cells are garnering increased attention in research related to
autoimmune diseases, including rheumatoid arthritis (RA). They play an essential role in the …