In tissue engineering, polyurethane-based implants have gained significant traction
because of their high compatibility and inertness. The implants therefore show fewer side …

Intervertebral disc (IVD) degeneration is the leading cause of low back pain, which
represents a highly prevalent chronic aging‐associated disorder with a large socio …

Disc nucleus replacement (NR) is a challenging surgical technique used as a medical
treatment for early-stage disc herniation to restore disc height and the biomechanical …

Hyaluronic acid (HA) is a key component of the intervertebral disc (IVD) that is widely
investigated as an IVD biomaterial. One persisting challenge is introducing materials …

Intervertebral disk (IVD) degeneration is associated with most cases of cervical and lumbar
spine pathologies, amongst which chronic low back pain has become the primary cause for …

Low back pain represents the highest burden of musculoskeletal diseases worldwide and
intervertebral disc degeneration is frequently associated with this painful condition. Even …

Biomaterials for regeneration of the intervertebral disc must meet complex requirements
conforming to biological, mechanical and clinical demands. Currently no consensus on their …

Intervertebral disc (IVD) degeneration is a major risk factor of low back pain. It is defined by a
progressive loss of the IVD structure and functionality, leading to severe impairments with …

Preclinical studies involving large animal models aim to recapitulate the clinical situation as
much as possible and bridge the gap from benchtop to bedside. To date, studies …

Intervertebral disc degeneration is strongly implicated as a cause of low-back pain. Stem cell-
based tissue engineering in treating intervertebral disc (IVD) degeneration recently obtained …