Cell death is an important component of the pathophysiology of cardiovascular disease. An
understanding of how cardiomyocytes die, and why regeneration of cells in the heart is …

Vascular smooth muscle cells (VSMCs) are the fundamental component of the medial layer
of arteries and are essential for arterial physiology and pathology. It is becoming …

Objectives Evidences demonstrate that sorafenib alleviates liver fibrosis via inhibiting HSC
activation and ECM accumulation. The underlying mechanism remains unclear. Ferroptosis …

Ferroptosis is a new form of regulated cell death (RCD) driven by iron-dependent lipid
peroxidation, which is morphologically and mechanistically distinct from other forms of RCD …

Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …

Ferroptosis is a programmed iron-dependent cell death characterized by accumulation of
lipid peroxides (LOOH) and redox disequilibrium. Ferroptosis shows unique characteristics …

In advanced atherosclerosis (AS), defective function-induced cell death leads to the
formation of the characteristic necrotic core and vulnerable plaque. The forms and …

A variety of programmed cell death types have been shown to participate in the loss of
smooth muscle cells (SMCs) during the development of aortic dissection (AD), but it is still …

Acute or chronic cellular stress resulting from aberrant metabolic and biochemical processes
may trigger a pervasive non-apoptotic form of cell death, generally known as ferroptosis …

Ferroptosis is a novel form of regulated cell death that has a close association with
mitochondrial dysfunction and is characterized by iron overload, the accumulation of …