Translational intracerebral hemorrhage research: has current neuroprotection research ARRIVEd at a standard for experimental design and reporting?
LJ Liddle, S Ralhan, DL Ward, F Colbourne - Translational stroke research, 2020 - Springer
One major aim of preclinical intracerebral hemorrhage (ICH) research is to develop and test
potential neuroprotectants. Published guidelines for experimental design and reporting …
potential neuroprotectants. Published guidelines for experimental design and reporting …
An ambiguous role for fever in worsening outcome after intracerebral hemorrhage
LJ Liddle, CA Dirks, M Almekhlafi… - Translational Stroke …, 2023 - Springer
Intracerebral hemorrhage (ICH) accounts for 10–15% of all strokes and leaves most
survivors with impairments. Fever, a rise in the thermoregulatory set point, complicates ICH …
survivors with impairments. Fever, a rise in the thermoregulatory set point, complicates ICH …
An update to the Monro–Kellie doctrine to reflect tissue compliance after severe ischemic and hemorrhagic stroke
High intracranial pressure (ICP) can impede cerebral blood flow resulting in secondary
injury or death following severe stroke. Compensatory mechanisms include reduced …
injury or death following severe stroke. Compensatory mechanisms include reduced …
Neuroprotection of minocycline by inhibition of extracellular matrix metalloproteinase inducer expression following intracerebral hemorrhage in mice
Intracerebral hemorrhage (ICH) is a severe neurological dysfunction and a medical
emergency with a high mortality rate. Minocycline ameliorates deficits in rodent models of …
emergency with a high mortality rate. Minocycline ameliorates deficits in rodent models of …
Intracranial pressure dysfunction following severe intracerebral hemorrhage in middle-aged rats
ACJ Kalisvaart, AH Abrahart, AT Coney, S Gu… - Translational Stroke …, 2023 - Springer
Rising intracranial pressure (ICP) aggravates secondary injury and heightens risk of death
following intracerebral hemorrhage (ICH). Long-recognized compensatory mechanisms that …
following intracerebral hemorrhage (ICH). Long-recognized compensatory mechanisms that …
Glibenclamide does not improve outcome following severe collagenase-induced intracerebral hemorrhage in rats
Intracerebral hemorrhage (ICH) is a devastating insult with few effective treatments. Edema
and raised intracranial pressure contribute to poor outcome after ICH. Glibenclamide blocks …
and raised intracranial pressure contribute to poor outcome after ICH. Glibenclamide blocks …
[HTML][HTML] Stroke and translational research–review of experimental models with a focus on awake ischaemic induction and anaesthesia
Animal models are an indispensable tool in the study of ischaemic stroke with hundreds of
drugs emerging from the preclinical pipeline. However, all of these drugs have failed to …
drugs emerging from the preclinical pipeline. However, all of these drugs have failed to …
[HTML][HTML] A translational perspective on intracranial pressure responses following intracerebral hemorrhage in animal models
As with ischemic and traumatic brain injury, raised intracranial pressure (ICP) is a common
life-threatening complication of intracerebral hemorrhage (ICH). Elevated ICP can lead to …
life-threatening complication of intracerebral hemorrhage (ICH). Elevated ICP can lead to …
Relationship between edema and intracranial pressure following intracerebral hemorrhage in rat
ACJ Kalisvaart, NA Bahr, F Colbourne - Frontiers in Stroke, 2023 - frontiersin.org
Elevated intracranial pressure (ICP) is a potentially fatal consequence of intracerebral
hemorrhage (ICH). As the mass of the hematoma and regional edema builds, ICP rises and …
hemorrhage (ICH). As the mass of the hematoma and regional edema builds, ICP rises and …
Early fever in patients with primary intracerebral hemorrhage is associated with worse long-term functional outcomes: a prospective study
WC Tseng, YH Chiu, YC Chen, HS Chen, MY Hsiao - BMC neurology, 2023 - Springer
Background Primary intracerebral hemorrhage (ICH) accounts for 85% of ICH cases and is
associated with high morbidity and mortality rates. Fever can cause secondary injury after …
associated with high morbidity and mortality rates. Fever can cause secondary injury after …