Chromatin regulatory proteins are increasingly recognized as potential new drug targets.
Many of these proteins harbor one or more so called 'reader domains' that recognize …

Histone methylation reader domains are protein modules that recognize specific histone
methylation marks, such as methylated or unmethylated lysine or arginine residues on …

SMNDC1 is a Tudor domain protein that recognizes di-methylated arginines and controls
gene expression as an essential splicing factor. Here, we study the specific contributions of …

Methylation of arginine (Arg) residues on histones creates a new binding epitope, enabling
recognition by aromatic cage binding pockets in Tudor domains; these protein–protein …

SET domain bifurcated protein 1 (SETDB1) is a histone lysine methyltransferase that
promotes the silencing of some tumour suppressor genes and is overexpressed in many …

Reader domains that recognize methylated lysine and arginine residues on histones play a
role in the recruitment, stabilization, and regulation of chromatin regulatory proteins …

Over the past years, growing interest toward post-translational modifications (PTMs) of
histones and nonhistone proteins has prompted academia and industrial research groups to …

Development of inhibitors for histone methyllysine reader proteins is an active area of
research due to the importance of reader protein–methyllysine interactions in transcriptional …

The methyl-lysine reader protein SPIN1 plays important roles in various human diseases.
However, targeting methyl-lysine reader proteins has been challenging. Very few cellularly …

SPIN1 is a histone methylation reader, which can epigenetically control multiple
tumorigenesis-associated signaling pathways, including the Wnt, PI3K/AKT, and RET …