The rapid increase in drug-resistant infections has presented a serious challenge to
antimicrobial therapies. The failure of the most potent antibiotics to kill “superbugs” …

Antimicrobial peptides (AMPs) are showing increasing promise as potential candidate
antibacterial drugs in the face of the rapidly emerging bacterial resistance to conventional …

Multicellular organisms live, by and large, harmoniously with microbes. The cornea of the
eye of an animal is almost always free of signs of infection. The insect flourishes without …

Antimicrobial peptides are an abundant and diverse group of molecules that are produced
by many tissues and cell types in a variety of invertebrate, plant and animal species. Their …

Permeation of the cell membrane leading to cell death is a mechanism used by a large
number of membrane-lytic peptides. Some are linear, mostly helical, and others contain one …

Water‐membrane soluble protein and peptide toxins are used in the defense and offense
systems of all organisms, including plants and humans. A major group includes …

Abstract The" BH3-only" proteins of the BCL-2 family require" multidomain" proapoptotic
members BAX and BAK to release cytochrome c from mitochondria and kill cells. We find …

We report the existence of a previously unknown antimicrobial domain near the N-terminus
of lactoferrin in a region distinct from its iron-binding sites. A single active peptide …

The increasing resistance of bacteria to conventional antibiotics resulted in a strong effort to
develop antimicrobial compounds with new mechanisms of action. Antimicrobial peptides …

Antimicrobial peptides (AMPs) are essential elements of thehost defense system.
Characterized by heterogenous structures and broad‐spectrumaction, they are promising …