Paramagnetic chemical probes have been used in electron paramagnetic resonance (EPR)
and nuclear magnetic resonance (NMR) spectroscopy for more than four decades. Recent …

Although fragment-based drug discovery (FBDD) has been successfully implemented and
well-explored for protein targets, its feasibility for RNA targets is emerging. Despite the …

The coronavirus disease pandemic caused by infection with the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has affected the global healthcare system. As low …

The characterization of protein–ligand interaction modes becomes recalcitrant in the NMR
intermediate exchange regime as the interface resonances are broadened beyond …

Delineation of protein–ligand interaction modes is key for rational drug discovery. The
availability of complex crystal structures is often limited by the aqueous solubility of the …

Considerable developments have been observed in fragment-based lead/drug discovery
(FBLD/FBDD) recently, with four drugs approved and many others under investigation …

Severe acute respiratory syndrome-coronavirus-1/2 (SARS-CoV-1/2) macrodomain 3
(Mac3) is critical for replication and transcription of the viral genome and is therefore a …

Cannabinoid receptor interacting protein 1a (CRIP1a) modulates CB 1 cannabinoid receptor
G-protein coupling in part by altering the selectivity for Gα i subtype activation, but the …

To further comprehensively study the intramolecular weak interaction of the gaseous TKX‐
50 molecule, the two conformations of the TKX‐50 molecule were analyzed via the …

The TDP-43 is originally a nuclear protein but translocates to the cytoplasm in the
pathological condition. TDP-43, as an RNA-binding protein, consists of two RNA …