Synthetic organic chemistry is based on the concourse of reagents and catalysts to achieve
the clean formation of new bonds, and appropriate protecting groups are required to prevent …

Peptides are an important class of molecules with diverse biological activities. Many
endogenous peptides, especially neuropeptides and peptide hormones, play critical roles in …

The cycloaddition of azides to alkynes is one of the most important synthetic routes to 1 H-[1,
2, 3]-triazoles. Here a novel regiospecific copper (I)-catalyzed 1, 3-dipolar cycloaddition of …

Pure α-azido acids were prepared using an efficient diazo transfer method followed by
buffered workup. These building blocks were used to prepare small peptides on Wang resin …

A catalytic regio-and enantioselective haloazidation reaction with a chiral iron (II) complex
catalyst under mild reaction conditions was reported. By this approach, the stereoselective α …

A general method for synthesizing α-hydroxy N-acylindoles in one-pot via an acid-catalyzed
condensation of a convertible isonitrile with water and various aldehydes is presented …

Cyclodepsipeptides are cyclic peptides in which at least one amide link on the backbone is
replaced with an ester link. These natural products present a high structural diversity that …

Backbone N‐substitution of peptides (N‐Me and N‐alkyl) has become of special interest as
a chemical tool for peptide lead modification, either to improve biological activity or to …

The azide-based carbamate or carbonate protecting group (Azoc) shown above can be
removed in less than 2 min under neutral conditions using trimethyl or tributyl phosphine as …

Peptide azides acquired growing impact because of application in bioconjugation via 'click
chemistry'or Staudinger ligation. Furthermore, there are many methods established in …