The pathogenesis of periodontitis involves a complex immune/inflammatory cascade that is
initiated by the bacteria of the oral biofilm that forms naturally on the teeth. The susceptibility …

First identified by Said and Mutt some 30 years ago, the vasoactive intestinal peptide (VIP)
was originally isolated as a vasodilator peptide. Subsequently, its biochemistry was …

It is generally accepted that the nervous system contributes to the pathophysiology of
peripheral inflammation, and a neurogenic component has been implicated in many …

The presence of macromolecular forms of VIP was initially reported in certain pancreatic-
islet and neurogenic tumors producing the peptide (13). This led to the demonstration that …

Research on VIP continues at a rapid pace. Recent progress includes: insights into its
biosynthesis (and that of a closely related PHI-like peptide) and its neuronal localization …

Vasoactive intestinal peptide (VIP) is a neuropeptide with a broad distribution in the body
that exerts very important pleiotropic functions in several systems. The present work reviews …

The neuroendocrine and immune systems are coordinated to maintain the homeostasis of
the organism, generating bidirectional communication through shared mediators and …

There is increasing evidence for a bidirectional communications system between the
immune system and the brain. Many of the substances involved in this communication …

Extracts of purified human eosinophils had a mean concentration of 72 fmol of
immunoreactive vasoactive intestinal peptide and 21 fmol of substance P per 10 7 …

Publisher Summary Although the goals of studies of neuroimmunology are to elucidate the
bases of integrated physiological events, most of the tangible accomplishments have been …