Schizophrenia is a debilitating psychiatric disorder that is treated with antipsychotics.
However, despite their efficacy, antipsychotics increase the risk of metabolic disorders in a …

Cholesterol is an essential molecule of life, and its synthesis can be inhibited by both
genetic and nongenetic mechanisms. Hundreds of chemicals that we are exposed to in our …

Neonatal hypoxic-ischemic brain injury (HIBI) results in part from excess reactive oxygen
species and iron-dependent lipid peroxidation (ie ferroptosis). The vitamin D precursor 7 …

The concurrent use of several medications is a common practice in the treatment of complex
psychiatric conditions. One such commonly used combination is aripiprazole (ARI), an …

Polypharmacy is commonly used to treat psychiatric disorders. These combinations often
include drugs with sterol biosynthesis inhibiting side effects, including the antipsychotic …

De novo sterol synthesis is a critical homeostatic mechanism in the brain that begins during
early embryonic development and continues throughout life. Multiple medications have …

Lipid rafts, specialised microdomains within cell membranes, play a central role in
orchestrating various aspects of neurodevelopment, ranging from neural differentiation to …

The objective of this study was to establish the pharmacokinetics of a single oral dose of
trazodone in the Hispaniolan Amazon parrot (Amazona ventralis). Trazodone is a selective …