All solid tumours require a vascular supply in order to progress. Although the ability to
induce angiogenesis (new blood vessel growth) has long been regarded as essential to this …

Metronomic chemotherapy describes the close, regular administration of chemotherapy
drugs at less-toxic doses over prolonged periods of time. In 2015, the results of randomized …

Artificial intelligence (AI) approaches have the potential to affect several facets of cancer
therapy. These include drug discovery and development and how these drugs are clinically …

Metronomic chemotherapy, continuous and dose‐dense administration of chemotherapeutic
drugs with lowered doses, is being evaluated for substituting, augmenting, or appending …

Metronomic dosing of chemotherapy—defined as frequent administration at lower doses—
has been shown to be more efficacious than maximum tolerated dose treatment in …

Nanomedicine offered hope for improving the treatment of cancer but the survival benefits of
the clinically approved nanomedicines are modest in many cases when compared to …

Despite historically known as “junk” DNA, nowadays non-coding RNA transcripts (ncRNAs)
are considered as fundamental players in various physiological and pathological conditions …

Many cancers appear to activate intrinsic antioxidant systems as a means to counteract
oxidative stress. Some cancers, such as clear cell renal cell carcinoma (ccRCC), require …

Hypoxia (low O 2) is a pathobiological hallmark of solid cancers, resulting from the
imbalance between cellular O 2 consumption and availability. Hypoxic cancer cells (CCs) …

Clear cell renal cell carcinoma (ccRCC) accounts for∼ 80% of all RCC, and biallelic Von
Hippel–Lindau (VHL) gene defects occur in∼ 75% of sporadic ccRCC. The …