Cartilage oligomeric matrix protein (COMP) is a large pentameric glycoprotein that interacts
with multiple extracellular matrix proteins in cartilage and other tissues. While, COMP is …

Vascular remodeling is the adaptive response to various physiological and
pathophysiological alterations that are closely related to aging and vascular diseases …

Background Critically ill patients diagnosed with COVID-19 may develop a pro-thrombotic
state that places them at a dramatically increased lethal risk. Although platelet activation is …

Background: The metalloprotease ADAMTS-7 (a disintegrin and metalloproteinase with
thrombospondin type 1 motif 7) is a novel locus associated with human coronary …

Cartilage oligomeric matrix protein (COMP) is an extracellular matrix (ECM) glycoprotein that
is critical for collagen assembly and ECM stability. Mutations of COMP cause endoplasmic …

Postural orthostatic tachycardia syndrome (POTS) is a cardiovascular autonomic disorder
characterized by excessive heart rate increase on standing, leading to debilitating symptoms …

Compelling evidence has revealed that biased activation of G protein-coupled receptor
(GPCR) signaling, including angiotensin II (AngII) receptor type 1 (AT1) signaling, plays …

Limited proteolysis of thrombospondins is a powerful mechanism to ensure dynamic tuning
of their activities in the extracellular space. Thrombospondins are multifunctional …

Cancer stem cell populations are important for the initiation, progression and metastasis of
tumors. The mechanisms governing cancer stem cell control are only partially understood …

Rationale: Intimal calcification is highly correlated with atherosclerotic plaque burden, but
the underlying mechanism is poorly understood. We recently reported that cartilage …