Ins and outs of the TCA cycle: the central role of anaplerosis

M Inigo, S Deja, SC Burgess - Annual review of nutrition, 2021 - annualreviews.org
The reactions of the tricarboxylic acid (TCA) cycle allow the controlled combustion of fat and
carbohydrate. In principle, TCA cycle intermediates are regenerated on every turn and can …

Management of NAFLD: a stage-based approach

ME Rinella, AJ Sanyal - Nature reviews Gastroenterology & hepatology, 2016 - nature.com
NAFLD is the most prevalent form of liver disease in the USA, affecting an estimated 30% of
the population. The condition is associated with increased mortality related to cardiovascular …

Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease

NE Sunny, EJ Parks, JD Browning, SC Burgess - Cell metabolism, 2011 - cell.com
Approximately one-third of the US population has nonalcoholic fatty liver disease (NAFLD),
a condition closely associated with insulin resistance and increased risk of liver injury …

Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver [S]

S Satapati, NE Sunny, B Kucejova, X Fu, TT He… - Journal of lipid …, 2012 - ASBMB
The manner in which insulin resistance impinges on hepatic mitochondrial function is
complex. Although liver insulin resistance is associated with respiratory dysfunction, the …

[HTML][HTML] Short-term weight loss and hepatic triglyceride reduction: evidence of a metabolic advantage with dietary carbohydrate restriction

JD Browning, JA Baker, T Rogers, J Davis… - The American journal of …, 2011 - Elsevier
Background: Individuals with nonalcoholic fatty liver disease (NAFLD) have excess
intrahepatic triglycerides. This is due, in part, to increased hepatic synthesis of fat from …

[HTML][HTML] Impaired ketogenesis and increased acetyl-CoA oxidation promote hyperglycemia in human fatty liver

JA Fletcher, S Deja, S Satapati, X Fu, SC Burgess… - JCI insight, 2019 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent, and potentially morbid,
disease that affects one-third of the US population. Normal liver safely accommodates lipid …

The effect of short-term fasting on liver and skeletal muscle lipid, glucose, and energy metabolism in healthy women and men

JD Browning, J Baxter, S Satapati, SC Burgess - Journal of lipid research, 2012 - ASBMB
Fasting promotes triglyceride (TG) accumulation in lean tissues of some animals, but the
effect in humans is unknown. Additionally, fasting lipolysis is sexually dimorphic in humans …

Nutrition and nonalcoholic fatty liver disease: current perspectives

MV Chakravarthy, T Waddell… - Gastroenterology …, 2020 - gastro.theclinics.com
Author contributions: MV Chakravarthy and T. Waddell reviewed and summarized literature,
created content, drafted the article, and created reference lists and figures; R. Banerjee …

Resistance training in overweight women on a ketogenic diet conserved lean body mass while reducing body fat

PT Jabekk, IA Moe, HD Meen, SE Tomten… - Nutrition & …, 2010 - Springer
Background The aim of the present study was to compare the effects of 10 weeks resistance
training in combination with either a regular diet (Ex) or a low carbohydrate, ketogenic diet …

[HTML][HTML] Dietary Regulation of Hepatic Triacylglycerol Content—the Role of Eucaloric Carbohydrate Restriction with Fat or Protein Replacement

AM Lundsgaard, KN Bojsen-Møller, B Kiens - Advances in Nutrition, 2023 - Elsevier
Accumulation of hepatic triacylglycerol (TG) is highly associated with impaired whole-body
insulin-glucose homeostasis and dyslipidemia. The summarized findings from human …