The discovery of Notch in Drosophila melanogaster nearly a century ago opened the door to
an ever-widening understanding of cellular processes that are controlled or influenced by …

Notch receptors influence cellular behavior by participating in a seemingly simple signaling
pathway, but outcomes produced by Notch signaling are remarkably varied depending on …

Summary p53 is a potent tumor suppressor, whose biological effects are largely due to its
function as a transcriptional regulator. Here we report that, in addition to regulating the …

T cells are the key mediators in cell-mediated immunity. Their development and maturation
involve a complex variety of interactions with nonlymphoid cell products and receptors …

The Notch signaling pathway regulates many aspects of embryonic development, as well as
differentiation processes and tissue homeostasis in multiple adult organ systems …

The activities of p53 cover diverse aspects of cell biology, including cell cycle control,
apoptosis, metabolism, fertility, differentiation and cellular reprogramming. Although loss of …

Evolutionarily conserved Notch plays a critical role in embryonic development and cellular
self-renewal. It has both tumour suppressor and oncogenic activity, the latter of which is …

Members of the Notch family of transmembrane receptors play an important role in cell fate
determination. Over the past decade, a role for Notch in the pathogenesis of hematologic …

Abstract The chromosomal translocation t (7; 9) in human T-cell acute lymphoblastic
leukaemia (T-ALL) results in deregulated expression of a truncated, activated form of Notch …

High expression of Notch-1 and Jagged-1 mRNA correlates with poor prognosis in breast
cancer. Elucidating the cross-talk between Notch and other major breast cancer pathways is …