Immune-related toxicities of checkpoint inhibitors: mechanisms and mitigation strategies

RJ Sullivan, JS Weber - Nature reviews Drug discovery, 2022 - nature.com
The immune-related adverse events associated with treatment with immune checkpoint
inhibitors result in significant morbidity for patients as well as considerable cost to the health …

Fatal toxic effects associated with immune checkpoint inhibitors: a systematic review and meta-analysis

DY Wang, JE Salem, JV Cohen, S Chandra… - JAMA …, 2018 - jamanetwork.com
Importance Immune checkpoint inhibitors (ICIs) are now a mainstay of cancer treatment.
Although rare, fulminant and fatal toxic effects may complicate these otherwise …

Management of immunotherapy-related toxicities, version 1.2019, NCCN clinical practice guidelines in oncology

JA Thompson, BJ Schneider, J Brahmer… - Journal of the National …, 2019 - jnccn.org
The aim of the NCCN Guidelines for Management of Immunotherapy-Related Toxicities is to
provide guidance on the management of immune-related adverse events resulting from …

EULAR points to consider for the diagnosis and management of rheumatic immune-related adverse events due to cancer immunotherapy with checkpoint inhibitors

M Kostine, A Finckh, CO Bingham, K Visser… - Annals of the …, 2021 - ard.bmj.com
Background Rheumatic and musculoskeletal immune-related adverse events (irAEs) are
observed in about 10% of patients with cancer receiving checkpoint inhibitors (CPIs). Given …

Paraneoplastic neurological syndromes in the era of immune-checkpoint inhibitors

F Graus, J Dalmau - Nature Reviews Clinical Oncology, 2019 - nature.com
Paraneoplastic neurological syndromes (PNSs) comprise a group of disorders that can
affect any part of the nervous system in patients with cancer and frequently result from …

Severe neurological toxicity of immune checkpoint inhibitors: growing spectrum

D Dubey, WS David, KL Reynolds, DF Chute… - Annals of …, 2020 - Wiley Online Library
Expanding use of immune‐checkpoint inhibitors (ICIs) underscores the importance of
accurate diagnosis and timely management of neurological immune‐related adverse events …

Encephalitis induced by immune checkpoint inhibitors: a systematic review

R Velasco, M Villagrán, M Jové, M Simó… - JAMA …, 2021 - jamanetwork.com
Importance Encephalitis is a severe immune-related adverse event secondary to treatment
with immune checkpoint inhibitors (ICIs). The spectrum of ICI-induced encephalitis (ICI-iE) …

Neurological complications of immune checkpoint inhibitors: what happens when you 'take the brakes off'the immune system

MC Dalakas - Therapeutic advances in neurological …, 2018 - journals.sagepub.com
Patients with advanced malignancies treated with immune checkpoint inhibitors are at
increased risk for developing immune-related neurological complications. It is a …

Neuromuscular adverse events associated with anti-PD-1 monoclonal antibodies: systematic review

A Johansen, SJ Christensen, D Scheie, JLS Højgaard… - Neurology, 2019 - AAN Enterprises
Neuromuscular adverse events following cancer treatment with anti-programmed cell death
protein 1 (PD-1) monoclonal antibodies are relatively rare, yet potentially fatal. We …

Current progresses and challenges of immunotherapy in triple-negative breast cancer

K Mediratta, S El-Sahli, V D'Costa, L Wang - Cancers, 2020 - mdpi.com
Simple Summary The breakthrough of immunotherapy in melanoma has generated a
glimmer of hope for lethal triple negative breast cancer (TNBC). This review summarizes the …