Cellular pathways in response to ionizing radiation and their targetability for tumor radiosensitization
P Maier, L Hartmann, F Wenz, C Herskind - International journal of …, 2016 - mdpi.com
During the last few decades, improvements in the planning and application of radiotherapy
in combination with surgery and chemotherapy resulted in increased survival rates of tumor …
in combination with surgery and chemotherapy resulted in increased survival rates of tumor …
Autophagy as a target for anticancer therapy
F Janku, DJ McConkey, DS Hong… - Nature reviews Clinical …, 2011 - nature.com
Autophagy is an important homeostatic cellular recycling mechanism responsible for
degrading unnecessary or dysfunctional cellular organelles and proteins in all living cells …
degrading unnecessary or dysfunctional cellular organelles and proteins in all living cells …
[HTML][HTML] Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health
WH Chappell, LS Steelman, JM Long, RC Kempf… - Oncotarget, 2011 - ncbi.nlm.nih.gov
Abstract The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by
genetic alterations in upstream signaling molecules such as receptor tyrosine kinases …
genetic alterations in upstream signaling molecules such as receptor tyrosine kinases …
Inhibition of Ras for cancer treatment: the search continues
AT Baines, D Xu, CJ Der - Future medicinal chemistry, 2011 - Taylor & Francis
The RAS oncogenes (HRAS, NRAS and KRAS) comprise the most frequently mutated class
of oncogenes in human cancers (33%), thus stimulating intensive effort in developing anti …
of oncogenes in human cancers (33%), thus stimulating intensive effort in developing anti …
Cytometric assessment of mitochondria using fluorescent probes
C Cottet‐Rousselle, X Ronot, X Leverve… - Cytometry Part …, 2011 - Wiley Online Library
Mitochondria are most important organelles in the survival of eukaryotic aerobic cells
because they are the primary producers of ATP, regulators of ion homeostasis or redox …
because they are the primary producers of ATP, regulators of ion homeostasis or redox …
Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations
J LoPiccolo, GM Blumenthal, WB Bernstein… - Drug Resistance …, 2008 - Elsevier
The PI3K/Akt/mTOR pathway is a prototypic survival pathway that is constitutively activated
in many types of cancer. Mechanisms for pathway activation include loss of tumor …
in many types of cancer. Mechanisms for pathway activation include loss of tumor …
Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy
P Maycotte, S Aryal, CT Cummings, J Thorburn… - Autophagy, 2012 - Taylor & Francis
Chloroquine (CQ) is a 4-aminoquinoline drug used for the treatment of diverse diseases. It
inhibits lysosomal acidification and therefore prevents autophagy by blocking …
inhibits lysosomal acidification and therefore prevents autophagy by blocking …
[HTML][HTML] Endocytosis-mediated mitochondrial transplantation: Transferring normal human astrocytic mitochondria into glioma cells rescues aerobic respiration and …
C Sun, X Liu, B Wang, Z Wang, Y Liu, C Di, J Si, H Li… - Theranostics, 2019 - ncbi.nlm.nih.gov
Emerging evidence indicates that reprogramming of energy metabolism involving
disturbances in energy production from a defect in cellular respiration with a shift to …
disturbances in energy production from a defect in cellular respiration with a shift to …
Bcl‐2 and Bcl‐xL play important roles in the crosstalk between autophagy and apoptosis
F Zhou, Y Yang, D Xing - The FEBS journal, 2011 - Wiley Online Library
Autophagy and apoptosis play important roles in the development, cellular homeostasis
and, especially, oncogenesis of mammals. They may be triggered by common upstream …
and, especially, oncogenesis of mammals. They may be triggered by common upstream …