Excitotoxicity is one of the primary mechanisms of cell loss in a variety of diseases of the
central and peripheral nervous systems. Other than the previously established signaling …

Most traumatic brain injuries (TBIs) during military deployment or training are clinically “mild”
and frequently caused by non-impact blast exposures. Experimental models were …

Traumatic Brain Injury (TBI) is a major cause of disability and mortality, particularly among
the elderly, yet our mechanistic understanding of how age renders the post-traumatic brain …

Simple Summary Traumatic brain injury (TBI) is a significant risk factor for the development
of sleep and circadian rhythm impairments. In order to understand if TBI models with …

NMDARs are ionotropic glutamate receptors widely expressed in the CNS, where they
mediate phenomena as diverse as neurotransmission, information processing …

Memories are stored as ensembles of engram neurons and their successful recall involves
the reactivation of these cellular networks. However, significant gaps remain in connecting …

Mild traumatic brain injury (mTBI) mostly causes transient symptoms, but repeated (r) mTBI
can lead to neurodegenerative processes. Diagnostic tools to evaluate the presence of …

Subconcussive head impacts are associated with the development of acute and chronic
cognitive deficits. We recently reported that high-frequency head impact (HFHI) causes …

Introduction Neonatal hypoxia is a common cause of early-life seizures. Both hypoxia-
induced seizures (HS), and the drugs used to treat them (eg, phenobarbital, PB), have been …

High throughput RNA sequencing experiments are widely conducted and analyzed to
identify differentially expressed genes (DEGs). The statistical models calculated for this task …