The skeleton is an exquisitely sensitive and archetypal T3-target tissue that demonstrates
the critical role for thyroid hormones during development, linear growth, and adult bone …

BACKGROUND: Tissue homeostasis depends on the balance between cell proliferation and
differentiation. Thyroid hormones (THs), through binding to their nuclear receptors, can …

The hypothalamic–pituitary–thyroid axis plays a key role in skeletal development,
acquisition of peak bone mass and regulation of adult bone turnover. Euthyroid status is …

Background As an endocrine organ, the thyroid acts on the entire body by secreting a series
of hormones, and bone is one of the main target organs of the thyroid. Summary This review …

Thyroid hormone induces tumor cell and blood vessel cell proliferation via a cell surface
receptor on heterodimeric integrin αvβ3. We investigated the role of thyroid hormone …

The present review traces the road leading to discovery of L-thyroxine, thyroid hormone (3,
5, 3-triiodo-L-thyronine, T3) and its cognate nuclear receptors. Thyroid hormone is a …

Thyroid hormones (TH) are important modulators of bone remodeling and thus, thyroid
diseases, in particular hyperthyroidism, are able to compromise bone quality and fracture …

Thyroid hormone plays an essential role in myogenesis, the process required for skeletal
muscle development and repair, although the mechanisms have not been established …

Thyroid hormone (TH) is essential for skeletal development from the late fetal life to the
onset of puberty. During this large window of actions, TH has key roles in endochondral and …

At thyroid hormone response elements on specific genes, complexes of nuclear thyroid
hormone receptors (TRs) and 3, 5, 3′-triiodo-L-thyronine (T3), coactivator or corepressor …