Targeting NMDA receptors in stroke: new hope in neuroprotection
QJ Wu, M Tymianski - Molecular brain, 2018 - Springer
Abstract NMDA (N-methyl-d-aspartate) receptors (NMDARs) play a central role in excitotoxic
neuronal death caused by ischemic stroke, but NMDAR channel blockers have failed to be …
neuronal death caused by ischemic stroke, but NMDAR channel blockers have failed to be …
[HTML][HTML] Excitotoxicity and stroke: identifying novel targets for neuroprotection
Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …
Tau protein kinases: involvement in Alzheimer's disease
Tau phosphorylation is regulated by a balance between tau kinase and phosphatase
activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau …
activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau …
Functions of p38 MAP kinases in the central nervous system
Mitogen-activated protein (MAP) kinases are a central component in signaling networks in a
multitude of mammalian cell types. This review covers recent advances on specific functions …
multitude of mammalian cell types. This review covers recent advances on specific functions …
Oxidative stress in ischemic brain damage: mechanisms of cell death and potential molecular targets for neuroprotection
H Chen, H Yoshioka, GS Kim, JE Jung… - Antioxidants & redox …, 2011 - liebertpub.com
Significant amounts of oxygen free radicals (oxidants) are generated during cerebral
ischemia/reperfusion, and oxidative stress plays an important role in brain damage after …
ischemia/reperfusion, and oxidative stress plays an important role in brain damage after …
MAPK signalling pathways as molecular targets for anti-inflammatory therapy—from molecular mechanisms to therapeutic benefits
B Kaminska - Biochimica et Biophysica Acta (BBA)-Proteins and …, 2005 - Elsevier
Excessive inflammation is becoming accepted as a critical factor in many human diseases,
including inflammatory and autoimmune disorders, neurodegenerative conditions, infection …
including inflammatory and autoimmune disorders, neurodegenerative conditions, infection …
p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases
S Kumar, J Boehm, JC Lee - Nature reviews Drug discovery, 2003 - nature.com
The p38 MAP kinases are a family of serine/threonine protein kinases that play important
roles in cellular responses to external stress signals. Since their identification about 10 years …
roles in cellular responses to external stress signals. Since their identification about 10 years …
Pathophysiology, treatment, and animal and cellular models of human ischemic stroke
Stroke is the world's second leading cause of mortality, with a high incidence of severe
morbidity in surviving victims. There are currently relatively few treatment options available …
morbidity in surviving victims. There are currently relatively few treatment options available …
Pathogenesis of acute stroke and the role of inflammasomes
Inflammation is an innate immune response to infection or tissue damage that is designed to
limit harm to the host, but contributes significantly to ischemic brain injury following stroke …
limit harm to the host, but contributes significantly to ischemic brain injury following stroke …
Reactive astrocytes and therapeutic potential in focal ischemic stroke
GR Choudhury, S Ding - Neurobiology of disease, 2016 - Elsevier
Astrocytes are specialized and the most abundant cell type in the central nervous system
(CNS). They play important roles in the physiology of the brain. Astrocytes are also critically …
(CNS). They play important roles in the physiology of the brain. Astrocytes are also critically …