Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans
and its incidence continues to rise. Although CSCC usually display a benign clinical …

Stratospheric ozone levels are near their lowest point since measurements began, so
current ultraviolet-B (UV-B) radiation levels are thought to be close to their maximum. Total …

Ultraviolet (UV) radiation in sunlight is the most prominent and ubiquitous physical
carcinogen in our natural environment. It is highly genotoxic but does not penetrate the body …

Repair of UV induced DNA damage is of key importance to UV-induced skin carcinogenesis.
Specific signal transduction pathways that regulate cell cycling, differentiation and apoptosis …

The multiple genetic hit model of cancer predicts that normal individuals should have stable
populations of cancer-prone, but noncancerous, mutant cells awaiting further genetic hits …

Ancient civilizations understood that sunlight provides visibility, warmth, health and vitality.
Their understanding of how sunlight provides these life-sustaining influences was immersed …

Aneuploidy is found in most solid tumours, but it remains unclear whether it is the cause or
the consequence of tumorigenesis. Using Plk4 overexpression (PLK4OE) during epidermal …

The transition from a normal cell to a neoplastic cell is a complex process and involves both
genetic and epigenetic changes. The process of carcinogenesis begins when the DNA is …

Exposure to solar radiation, particularly its ultraviolet (UV) B component, has a variety of
harmful effects on human health. Some of these effects include sunburn cell formation, basal …

Ultraviolet radiation from the sun damages human skin, resulting in an old and wrinkled
appearance. A substantial amount of circumstantial evidence indicates that photoaging …