HFIP in organic synthesis

HF Motiwala, AM Armaly, JG Cacioppo… - Chemical …, 2022 - ACS Publications
1, 1, 1, 3, 3, 3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating
solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic …

Pd-catalyzed cross-couplings: On the importance of the catalyst quantity descriptors, mol% and ppm

CS Horbaczewskyj, IJS Fairlamb - Organic Process Research & …, 2022 - ACS Publications
This Review examines parts per million (ppm) palladium concentrations in catalytic cross-
coupling reactions and their relationship with mole percentage (mol%). Most studies in …

Inhibition of microtubule dynamics in cancer cells by indole-modified latonduine derivatives and their metal complexes

C Wittmann, AS Sivchenko, F Bacher… - Inorganic …, 2022 - ACS Publications
Indolo [2, 3-d] benzazepines (indololatonduines) are rarely discussed in the literature. In this
project, we prepared a series of novel indololatonduine derivatives and their RuII and OsII …

Directed C–H Functionalization of C3-Aldehyde, Ketone, and Acid/Ester-Substituted Free (NH) Indoles with Iodoarenes via a Palladium Catalyst System

Y Taskesenligil, M Aslan, T Cogurcu… - The Journal of Organic …, 2022 - ACS Publications
Pd (II)-catalyzed C–H arylations of free (NH) indoles including different carbonyl directing
groups on C3-position with aryl iodides are demonstrated. Importantly, the reactions are …

Chemoselective reduction of nitroarenes, N-acetylation of arylamines, and one-pot reductive acetylation of nitroarenes using carbon-supported palladium catalytic …

B Zeynizadeh, F Mohammad Aminzadeh… - Research on Chemical …, 2021 - Springer
Developing and/or modifying fundamental chemical reactions using chemical industry-
favorite heterogeneous recoverable catalytic systems in the water solvent is very important …

Investigation of Pd‐PEPPSI catalysts and coupling partners towards direct C2‐arylation/heteroarylation of benzoxazole

A Gokanapalli, VKR Motakatla… - Applied …, 2021 - Wiley Online Library
2‐Aryl/heteroaryl‐substituted benzoxazoles are important heterocyclic motifs extensively
found in several bioactive molecules, pharmaceuticals and natural products. In view of the …

Heck reaction boosted heterocycle ring-closing and ring-opening rearrangement: A strategy for the synthesis of indolyl-type ligands

C Li, ZC Qi, JY Li, SD Yang - The Journal of Organic Chemistry, 2021 - ACS Publications
A novel method for P-involved heterocycle ring-closing–ring-opening rearrangement (HRR)
via the Heck reaction is disclosed. The approach enables direct installation of a phosphorus …