In the United States, the 20th century witnessed the emergence of a lung cancer epidemic
that peaked and began to decline by the century's end, a decline that continues today …

We review the molecular pathogenesis of lung cancer including alterations in dominant
oncogenes, recessive oncogenes/tumor suppressor genes, alterations in growth regulatory …

Because most colorectal carcinomas appear to arise from adenomas, studies of different
stages of colorectal neoplasia may shed light on the genetic alterations involved in tumor …

The ability of carcinomas to invade and to metastasize largely depends on the degree of
epithelial differentiation within the tumors, ie, poorly differentiated being more invasive than …

Allele loss is a hallmark of chromosome regions harboring recessive oncogenes. Lung
cancer frequently demonstrates loss of heterozygosity on 17p. Recent evidence suggests …

Frequent losses of chromosome 19p have recently been observed in sporadic lung
adenocarcinomas, targeting the location of a critical tumor suppressor gene. Here we …

To examine the extent and variation of allelic loss in a common adult tumor, polymorphic
DNA markers were studied from every nonacrocentric autosomal arm in 56 paired colorectal …

Small cell lung cancer (SCLC) has been associated with loss of heterozygosity at several
distinct genetic loci including chromosomes 3p, 13q, and 17p. To determine whether the …

Allele loss involving chromosome arm 3p is one of the most frequent and earliest known
genetic events in lung cancer pathogenesis and may affect several potential tumor …

Sporadic clear cell renal cell carcinoma (cRCC) is genetically characterized by the recurrent
loss of the short arm of chromosome 3, with a hotspot for copy number loss in the 3p21 …