The antiphospholipid syndrome is a prothrombotic disorder associated with autoantibodies.
It is associated with obstetrical complications (mainly spontaneous abortion) as well as …

Platelets are essential for physiological hemostasis and are central in pathological
thrombosis. These are their traditional and best known activities in health and disease. In …

The ex vivo generation of platelets from human-induced pluripotent cells (hiPSCs) is
expected to compensate donor-dependent transfusion systems. However, manufacturing the …

Achieving hemostasis following vascular injury requires the rapid accumulation of platelets
and fibrin. Here we used a combination of confocal intravital imaging, genetically …

The donor-dependent supply of platelets is frequently insufficient to meet transfusion needs.
To address this issue, we developed a clinically applicable strategy for the derivation of …

Phosphatidylserine (PtdSer) exposure on the surface of activated platelets requires the
action of a phospholipid scramblase (s), and serves as a scaffold for the assembly of the …

Background—Behçet disease (BD) is a systemic vasculitis with a broad range of organ
involvement, characterized by a multisystemic, immune-inflammatory disorder involving …

Systemic sclerosis (SSc) is manifested by fibrosis, vasculopathy and immune dysregulation.
So far, a unifying hypothesis underpinning these pathological events remains unknown …

Deep vein thrombosis (DVT) is a common condition characterized by the formation of an
occlusive blood clot in the venous vascular system, potentially complicated by detachment …

Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder mediated by
complexes between platelet factor 4 (PF4) and heparin or other polyanions, but the risk of …