[HTML][HTML] Harnessing TRAIL-induced cell death for cancer therapy: a long walk with thrilling discoveries
A Montinaro, H Walczak - Cell Death & Differentiation, 2023 - nature.com
Tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) can induce apoptosis
in a wide variety of cancer cells, both in vitro and in vivo, importantly without killing any …
in a wide variety of cancer cells, both in vitro and in vivo, importantly without killing any …
Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy
S Von Karstedt, A Montinaro, H Walczak - Nature Reviews Cancer, 2017 - nature.com
The discovery that the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) can
induce apoptosis of cancer cells without causing toxicity in mice has led to the in-depth study …
induce apoptosis of cancer cells without causing toxicity in mice has led to the in-depth study …
[HTML][HTML] A renal YY1-KIM1-DR5 axis regulates the progression of acute kidney injury
C Yang, H Xu, D Yang, Y Xie, M Xiong, Y Fan… - Nature …, 2023 - nature.com
Acute kidney injury (AKI) exhibits high morbidity and mortality. Kidney injury molecule-1
(KIM1) is dramatically upregulated in renal tubules upon injury, and acts as a biomarker for …
(KIM1) is dramatically upregulated in renal tubules upon injury, and acts as a biomarker for …
[HTML][HTML] Higher-order clustering of the transmembrane anchor of DR5 drives signaling
Receptor clustering on the cell membrane is critical in the signaling of many
immunoreceptors, and this mechanism has previously been attributed to the extracellular …
immunoreceptors, and this mechanism has previously been attributed to the extracellular …
[HTML][HTML] Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress
Disruption of protein folding in the endoplasmic reticulum (ER) activates the unfolded protein
response (UPR)—a signaling network that ultimately determines cell fate. Initially, UPR …
response (UPR)—a signaling network that ultimately determines cell fate. Initially, UPR …
Clustering of death receptor for apoptosis using nanoscale patterns of peptides
The nanoscale spatial organization of transmembrane tumor necrosis factor (TNF) receptors
has been implicated in the regulation of cellular fate. Accordingly, molecular tools that can …
has been implicated in the regulation of cellular fate. Accordingly, molecular tools that can …
NF‐κB targeting for overcoming tumor resistance and normal tissues toxicity
Radiotherapy and chemotherapy are two famous modalities in tumor‐targeted therapy that
lead to systemic and local toxicities for normal tissues. Moreover, several studies have …
lead to systemic and local toxicities for normal tissues. Moreover, several studies have …
[HTML][HTML] Apo2L/TRAIL and the death receptor 5 agonist antibody AMG 655 cooperate to promote receptor clustering and antitumor activity
JD Graves, JJ Kordich, TH Huang, J Piasecki, TL Bush… - Cancer cell, 2014 - cell.com
Death receptor agonist therapies have exhibited limited clinical benefit to date.
Investigations into why Apo2L/TRAIL and AMG 655 preclinical data were not predictive of …
Investigations into why Apo2L/TRAIL and AMG 655 preclinical data were not predictive of …
[HTML][HTML] Regulation of TNF-related apoptosis-inducing ligand signaling by glycosylation
O Micheau - International journal of molecular sciences, 2018 - mdpi.com
Tumor necrosis-factor related apoptosis-inducing ligand, also known as TRAIL or APO2L
(Apo-2 ligand), is a cytokine of the TNF superfamily acknowledged for its ability to trigger …
(Apo-2 ligand), is a cytokine of the TNF superfamily acknowledged for its ability to trigger …
Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation
Members of the tumor necrosis factor receptor superfamily (TNFRSF) are important
therapeutic targets that can be activated to induce death of cancer cells or stimulate …
therapeutic targets that can be activated to induce death of cancer cells or stimulate …