Within mammalian systems, there exists enormous opportunity to use synthetic gene circuits
to enhance phenotype-based drug discovery, to map the molecular origins of disease, and …

Instant and adequate handling of misfolded or otherwise aberrant proteins is of paramount
importance for maintaining protein homeostasis in cells. The ubiquitin/proteasome system …

Synthetic biology increasingly enables the construction of sophisticated functions in
mammalian cells. A particularly promising frontier combines concepts drawn from industrial …