[HTML][HTML] Advances in the diagnosis and early management of gestational trophoblastic disease

CM Joyce, B Fitzgerald, TV McCarthy, J Coulter… - BMJ …, 2022 - ncbi.nlm.nih.gov
Gestational trophoblastic disease describes a group of rare pregnancy related disorders that
span a spectrum of premalignant and malignant conditions. Hydatidiform mole (also termed …

Gestational trophoblastic neoplasia: novelties and challenges

ALM da Silva, K do Nascimento Monteiro, SY Sun… - Placenta, 2021 - Elsevier
Gestational trophoblastic diseases are a group of pregnancy-related disorders, originated
from trophoblast cells. They include benign and aggressive tumors, such as the invasive …

Predictors for single-agent resistance in FIGO score 5 or 6 gestational trophoblastic neoplasia: a multicentre, retrospective, cohort study

A Braga, G Paiva, E Ghorani, F Freitas… - The Lancet …, 2021 - thelancet.com
Background Patients with gestational trophoblastic neoplasia who have an International
Federation of Gynaecology and Obstetrics (FIGO) risk score of 5 or 6 usually receive non …

Anti-PD-1 therapy plus chemotherapy versus anti-PD-1 therapy alone in patients with high-risk chemorefractory or relapsed gestational trophoblastic neoplasia: a …

X Wang, W Cang, X Liu, Y Cheng, X Wan, F Feng… - …, 2023 - thelancet.com
Background Synergistic antitumor effects of immunotherapy and chemotherapy have been
demonstrated in several solid tumors. However, this combination strategy has not been …

Treatment of high-risk gestational trophoblastic neoplasia and chemoresistance/relapsed disease

A Braga, KM Elias, NS Horowitz… - Best Practice & Research …, 2021 - Elsevier
High-risk gestational trophoblastic neoplasia (GTN) has an increased risk of developing
chemoresistance to single-agent chemotherapy; therefore, the primary treatment should be …

Current chemotherapeutic options for the treatment of gestational trophoblastic disease

A Braga, G Paiva, CJ Cattai, KM Elias… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Gestational trophoblastic neoplasia (GTN) is a rare tumor that arises from
trophoblastic tissues with high remission rates after chemotherapy treatment. GTN can …

Perinatal outcomes of first pregnancy after chemotherapy for gestational trophoblastic neoplasia: a systematic review of observational studies and meta-analysis

JM Madi, MP Paganella, IE Litvin, M Viggiano… - American Journal of …, 2022 - Elsevier
Objective To assess perinatal outcomes of first pregnancy after remission from gestational
trophoblastic neoplasia and the impact of the time between the end of chemotherapy and …

Immunotherapy in the treatment of chemoresistant gestational trophoblastic neoplasia-systematic review with a presentation of the first 4 Brazilian cases

A Braga, E Balthar, LCS Souza, M Samora, M Rech… - Clinics, 2023 - SciELO Brasil
Objective To evaluate the efficacy of immunotherapy for GTN treatment after methotrexate-
resistance or in cases of multiresistant disease, through a systematic review, as well as to …

EMACO for treatment of gestational trophoblastic neoplasia: A multinational multicenter study

N Jareemit, S Therasakvichya, F Freitas, G Paiva… - Gynecologic …, 2023 - Elsevier
Objective To investigate the efficacy and toxicity of etoposide, methotrexate, actinomycin D
alternating with cyclophosphamide, and vincristine (EMACO) for treatment of gestational …

Neutrophil/lymphocyte ratio and other blood cell component counts are not associated with the development of postmolar gestational trophoblastic neoplasia

A Braga, AC Canelas, B Torres, I Maesta… - Plos one, 2022 - journals.plos.org
Objective To relate preevacuation platelet count and leukogram findings, especially
neutrophil/lymphocyte ratios (NLR) and platelet/lymphocyte ratios with the occurrence of …