Voltage-gated sodium and calcium channels are evolutionarily related transmembrane
signaling proteins that initiate action potentials, neurotransmission, excitation-contraction …

Voltage-gated sodium channels initiate action potentials in nerve and muscle, and voltage-
gated calcium channels couple depolarization of the plasma membrane to intracellular …

Arteriolar smooth muscle cells (SMCs) and capillary pericytes dynamically regulate blood
flow in the central nervous system in the face of fluctuating perfusion pressures. Pressure …

This review describes interactions between compounds, primarily dihydropyridines, that
block L-type calcium channels and drugs that cause dependence, and the potential …

Voltage-gated L-type Ca2+ channel (Cav1. 2) blockers (LCCBs) are major drugs for treating
hypertension, the preeminent risk factor for heart failure. Vascular smooth muscle cell …

The continuous emergence of severe acute respiratory coronavirus 2 (SARS-CoV-2)
variants and the increasing number of breakthrough infection cases among vaccinated …

Worldwide, hypertension is the leading risk factor for cardiovascular disease and death. An
estimated 122 million people, per the American Heart Association in 2023, have been …

Hereditary degeneration of photoreceptors has been linked to over-activation of Ca2+-
permeable channels, excessive Ca2+-influx, and downstream activation of Ca2+-dependent …

L-type Calcium Channels (LTCCs), also termed as Cav1, belong to voltage-gated calcium
channels (VGCCs/Cavs), which play a critical role in a wide spectrum of physiological …

KCNQ (Kv7) channels are voltage-gated, phosphatidylinositol 4, 5-bisphosphate-(PIP 2-)
modulated potassium channels that play essential roles in regulating the activity of neurons …