Abstract Cytochrome P450 2C19 (CYP2C19) is the main (or partial) cause for large
differences in the pharmacokinetics of a number of clinically important drugs. On the basis of …

The cytochrome P450 proteins (CYPs) are a family of haem proteins resulting from
expression of a gene super-family that currently contains around 1000 members in species …

The present study evaluates the worldwide frequency distribution of CYP2C19 alleles and
CYP2C19 metabolic phenotypes ('predicted'from genotypes and 'measured'with a probe …

Background and Objectives The genetically polymorphic cytochrome P450 enzymes 2C19
(CYP2C19) and 2D6 (CYP2D6) contribute to the metabolism of about 30% of all drugs. For …

Many antipsychotics, including perphenazine, zuclopenthixol, thioridazine, haloperidol and
risperidone, are metabolised to a significant extent by the polymorphic cytochrome P450 …

Aims The goal of this study was to determine the frequencies of important allelic variants of
CYP2C9, CYP2C19, CYP2E1 and DPYD in the Egyptian population and compare them with …

Introduction Racial and ethnic categories are frequently used in pharmacogenetics literature
to stratify patients; however, these categories can be inconsistent across different studies. To …

Human cytochrome P450 (CYP) is a superfamily of hemoproteins which oxidize a number of
endogenous compounds and xenobiotics. The human CYP2C subfamily consists of four …

CYP2C9 and CYP2C19 are important drug metabolizing enzymes and together metabolize
about 18% of currently available drugs. Some of the important groups of drugs that are …

Polymorphisms in the cytochrome P (CYP) 450 family may cause adverse drug responses in
individuals. Cytochrome P450 2C19 (CYP2C19) is a member of the CYP family, where the …