Deleterious genetic variation is abundant in wild populations, and understanding the
ecological and conservation implications of such variation is an area of active research …

Island ecosystems provide natural laboratories to assess the impacts of isolation on
population persistence. However, most studies of persistence have focused on a single …

Wildlife populations are becoming increasingly fragmented by anthropogenic development.
Small and isolated populations often face an elevated risk of extinction, in part due to …

Small and isolated wildlife populations face numerous threats to extinction, among which is
the deterioration of fitness due to an accumulation of deleterious genetic variation. Genomic …

The distribution of fitness effects is a key property in evolutionary genetics as it has
implications for several evolutionary phenomena including the evolution of sex and mating …

Dominance is a fundamental parameter in genetics, determining the dynamics of natural
selection on deleterious and beneficial mutations, the patterns of genetic variation in natural …

The distribution of fitness effects (DFE) describes the proportions of new mutations that have
different effects on reproductive fitness. Accurate measurements of the DFE are important …

The accurate estimation of the distribution of fitness effects (DFE) of new mutations is critical
for population genetic inference but remains a challenging task. While various methods …

The distribution of fitness effects (DFE) describes the proportions of new mutations that have
different effects on reproductive fitness. Accurate measurements of the DFE are important …

When a new mutation arises, what is the probability that it is recessive lethal? Wade et al.
find that fewer than 1% of nonsynonymous mutations in humans and Drosophila …