Neuropathy, or damage to the nerves of the peripheral nervous system, is a debilitating yet
surprisingly common and complex condition. Diabetic peripheral neuropathy (DPN) is a …

The worldwide diabetes epidemic is estimated to currently afflict almost 500 million persons.
Long-term diabetes damages multiple organ systems with the blood vessels, eyes, kidneys …

Objective Diabetic sensorimotor polyneuropathy (DSPN) affects approximately half of
diabetic patients leading to significant morbidity. There is impaired neurotrophic growth …

Objectives: Review the pathophysiology of diabetic neuropathy. Summarize the treatment of
diabetic neuropathy. Describe the potential complications of diabetic neuropathy. Outline the …

Background The purpose of this study was to establish the association between continuous
glucose monitoring (CGM)‐defined glycaemic variability (GV) and cardiovascular autonomic …

Objective The distal dying-back of the longest nerve fibres is a hallmark of diabetic
neuropathy, and impaired provision of energy in the form of adenosine triphosphate (ATP) …

Mitochondrial dysfunction is implicated in a variety of neurodegenerative diseases of the
nervous system. Peroxisome proliferator–activated receptor-γ coactivator-1α (PGC-1α) is a …

Aims To investigate whether multi-frequency measurement of vibration perception
thresholds (VPTs) can identify individuals with a high risk of developing diabetic foot ulcer or …

Diabetic neuropathy affects approximately 50% of diabetic patients. Down-regulation of
mitochondrial gene expression and function has been reported in both human tissues and in …

In peripheral nerve under hyperglycemic conditions high flux of d-glucose through the polyol
pathway drives an aberrant redox state contributing to neurodegeneration in diabetic …