Many drugs that target amyloid-β (Aβ) in Alzheimer disease (AD) have failed to demonstrate
clinical efficacy. However, four anti-Aβ antibodies have been shown to mediate the removal …

The β-sheet–rich amyloid core is the defining feature of protein aggregates associated with
neurodegenerative disorders. Recent investigations have revealed that there exist multiple …

NMR has the resolution and specificity to determine atomic-level protein structures of
isotopically labeled proteins in complex environments, and with the sensitivity gains …

Cerebral amyloid angiopathy (CAA) is associated with the accumulation of fibrillar Aβ
peptides upon and within the cerebral vasculature, which leads to loss of vascular integrity …

Cerebral amyloid angiopathy (CAA) is associated with the accumulation of fibrillar Aβ
peptides upon and within the cerebral vasculature, which leads to loss of vascular integrity …

With the sensitivity enhancements conferred by dynamic nuclear polarization (DNP), magic
angle spinning (MAS) solid state NMR spectroscopy experiments can attain the necessary …

The assembly of misfolded proteins into amyloid fibrils is associated with amyloidosis,
including neurodegenerative diseases such as Alzheimer's, Parkinson's and prion diseases …

Here, we report a new phenomenon in which lysozyme fibrils formed in a solution of acetic
acid spontaneously refold to a different polymorph through a disassembled intermediate …

Objective. This study aimed to determine the active components of Zhinao capsule (ZNC)
and the targets in treating Alzheimer's disease (AD) so as to investigate and explore the …

Aggregation of proteins is at the nexus of molecular processes crucial to aging, disease, and
employing proteins for biotechnology and medical applications. There has been much …