The central nervous system (CNS) receives information from afferent neurons, circulating
hormones, and absorbed nutrients and integrates this information to orchestrate the actions …

5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

Serotonin is a phylogenetically ancient biogenic amine that has played an integral role in
maintaining energy homeostasis for billions of years. In mammals, serotonin produced …

Accumulated evidence from genetic animal models suggests that the brain, particularly the
hypothalamus, has a key role in the homeostatic regulation of energy and glucose …

In the past decade, emerging synthetic biology technologies such as chemogenetics have
dramatically transformed how pharmacologists and systems biologists deconstruct the …

Background Lorcaserin is a selective serotonin 2C receptor agonist that could be useful in
reducing body weight. Methods In this double-blind clinical trial, we randomly assigned …

The central nervous system (CNS) controls food intake and energy expenditure via tight
coordinations between multiple neuronal populations. Specifically, two distinct neuronal …

The gastrointestinal peptide hormone ghrelin stimulates appetite in rodents and humans via
hypothalamic actions. We discovered expression of ghrelin in a previously uncharacterized …

The central melanocortin system is perhaps the best-characterized neuronal pathway
involved in the regulation of energy homeostasis. This collection of circuits is unique in …

Serotonin has been implicated in the control of satiety for almost four decades. Historically,
the insight that the appetite suppressant effect of fenfluramine is linked to serotonin has …