Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition
Cystic fibrosis (CF) is a lethal autosomal recessive disorder that afflicts more than 70,000
people. People with CF experience multi-organ dysfunction resulting from aberrant …
people. People with CF experience multi-organ dysfunction resulting from aberrant …
The potential role and regulatory mechanisms of MUC5AC in chronic obstructive pulmonary disease
J Li, Z Ye - Molecules, 2020 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is associated with high morbidity and
mortality globally. Studies show that airway mucus hypersecretion strongly compromises …
mortality globally. Studies show that airway mucus hypersecretion strongly compromises …
Targeting Epithelium Dysfunction and Impaired Nasal Biofilms to Treat Immunological, Functional, and Structural Abnormalities of Chronic Rhinosinusitis
K Petalas, J Goudakos, GN Konstantinou - International Journal of …, 2023 - mdpi.com
Chronic rhinosinusitis (CRS) with (CRSwNP) or without (CRSsNP) nasal polyps is a
prevalent and heterogeneous disorder existing as a spectrum of clinical conditions with …
prevalent and heterogeneous disorder existing as a spectrum of clinical conditions with …
Validation of the DNA Methylation Landscape of TFF1/TFF2 in Gastric Cancer
Z Qian, Y Jiang, C Shou, J Yu, D Huang, H Xie, L Zhou… - Cancers, 2022 - mdpi.com
Simple Summary The members of the TFF family have been illustrated to be tumor
suppressor genes in various malignancies. In this study, we first identified that TFF1/TFF2 …
suppressor genes in various malignancies. In this study, we first identified that TFF1/TFF2 …
Trefoil factor family: a troika for lung repair and regeneration
HL Rossi, JF Ortiz-Carpena, D Tucker… - American Journal of …, 2022 - atsjournals.org
Tissue damage in the upper and lower airways caused by mechanical abrasion, noxious
chemicals, or pathogenic organisms must be followed by rapid restorative processes; …
chemicals, or pathogenic organisms must be followed by rapid restorative processes; …
Decreased expression of TFF2 and decreased αGlcNAc glycosylation are malignant biomarkers of pyloric gland adenoma of the duodenum
K Yamanoi, C Fujii, A Nakayama, N Matsuura… - Scientific reports, 2023 - nature.com
Pyloric gland adenoma (PGA) is a duodenal neoplasm expressing MUC6 and is often
associated with high-grade dysplasia and adenocarcinoma. MUC6 secreted from the pyloric …
associated with high-grade dysplasia and adenocarcinoma. MUC6 secreted from the pyloric …
Eupatilin alleviates inflammation and epithelial-to-mesenchymal transition in chronic rhinosinusitis with nasal polyps by upregulating TFF1 and inhibiting the Wnt/β …
H Su, Y Zhao - 2024 - digitum.um.es
Background. Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial
inflammatory disease characterized by high prevalence and morbidity. However, its …
inflammatory disease characterized by high prevalence and morbidity. However, its …
Cell Type Catalog of Middle Turbinate Epithelium (Cell Catalog of Turbinate Epithelium)
F Mathews, VSK Tung, R Foronjy, M Boruk… - OTO …, 2023 - Wiley Online Library
Objective Single‐cell RNA‐sequencing of middle turbinate mucosa was performed to create
the first single‐cell transcriptome catalog of this part of the human body. Study Design Basic …
the first single‐cell transcriptome catalog of this part of the human body. Study Design Basic …
Cell type catalog of middle turbinate epithelium
F Mathews, VS Keng Tung, R Foronjy, M Boruk… - bioRxiv, 2022 - biorxiv.org
Importance Elucidation of the cellular makeup of the middle turbinate provides a foundation
for future studies of pathogenesis of sinonasal disease. Neural progenitors and pluripotent …
for future studies of pathogenesis of sinonasal disease. Neural progenitors and pluripotent …
A molecular atlas of proximal airway identifies subsets of known airway cell types revealing details of the unique molecular pathogenesis of Cystic Fibrosis
Introduction/Abstract Cystic fibrosis (CF) is a lethal autosomal recessive disorder that afflicts
in excess of 70,000 people globally. People with CF experience multi-organ dysfunction …
in excess of 70,000 people globally. People with CF experience multi-organ dysfunction …