[HTML][HTML] Protective effects of polysaccharides in neurodegenerative diseases

Y Wang, R Chen, Z Yang, Q Wen, X Cao… - Frontiers in Aging …, 2022 - frontiersin.org
Neurodegenerative diseases (NDs) are characterized by progressive degeneration and
necrosis of neurons, including Alzheimer's disease (AD), Parkinson's disease (PD) …

Mechanisms and structure-activity relationships of polysaccharides in the intervention of Alzheimer's disease: A review

J Tang, M Yousaf, YP Wu, Q Li, YQ Xu… - International Journal of …, 2023 - Elsevier
Alzheimer's disease (AD) is a complex neurodegenerative disease. Despite several
decades of research, the development of effective treatments and responses for Alzheimer's …

[HTML][HTML] Polysaccharides from Ganoderma lucidum promote cognitive function and neural progenitor proliferation in mouse model of Alzheimer's disease

S Huang, J Mao, K Ding, Y Zhou, X Zeng, W Yang… - Stem cell reports, 2017 - cell.com
Promoting neurogenesis is a promising strategy for the treatment of cognition impairment
associated with Alzheimer's disease (AD). Ganoderma lucidum is a revered medicinal …

[HTML][HTML] Codonopsis pilosula polysaccharide attenuates Aβ toxicity and cognitive defects in APP/PS1 mice

L Wan, Q Zhang, H Luo, Z Xu, S Huang, F Yang… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Abstract Codonopsis pilosula Polysaccharides (CPPs), a traditional Chinese medicine used
for thousands of years, is a potential neuroprotective polysaccharide via a relatively poorly …

[HTML][HTML] Codonopsis pilosula Polysaccharide Attenuates Tau Hyperphosphorylation and Cognitive Impairments in hTau Infected Mice

Q Zhang, Y Xia, H Luo, S Huang, Y Wang… - Frontiers in molecular …, 2018 - frontiersin.org
Codonopsis pilosula polysaccharide (CPPs), a natural products with potentially lower
toxicity and better bioavailability has been used in traditional Chinese medicine for 1000s of …

New insights into the role of fibroblast growth factors in Alzheimer's disease

R Alam, Y Mrad, H Hammoud, Z Saker, Y Fares… - Molecular Biology …, 2022 - Springer
Abstract Alzheimer's disease (AD), acknowledged as the most common progressive
neurodegenerative disorder, is the leading cause of dementia in the elderly. The …

Alzheimer's disease and Parkinson's disease: a review of current treatment adopting a nanotechnology approach

A Trompetero, A Gordillo, MC del Pilar… - Current …, 2018 - ingentaconnect.com
Neurodegenerative disorders (NDDs) are characterized by the progressive loss of structure
or neuron function, often associated with neuronal death. Treatments for neurodegenerative …

[HTML][HTML] Mini-GAGR, an intranasally applied polysaccharide, activates the neuronal Nrf2-mediated antioxidant defense system

K Murphy, K Llewellyn, S Wakser, J Pontasch… - Journal of Biological …, 2018 - ASBMB
Oxidative stress triggers and exacerbates neurodegeneration in Alzheimer's disease (AD).
Various antioxidants reduce oxidative stress, but these agents have little efficacy due to poor …

Molecular weight effects of low acyl gellan gum on antioxidant capacity and rheological properties

A Baawad, C Rice, T Hamil, K Murphy… - Journal of Food …, 2021 - Wiley Online Library
The current study investigated the antioxidant capacity of enzymatically cleaved low acyl
gellan gum (LA‐GAGR) fragments, named midi‐GAGR (MWv: 1.2× 105 Da) and mini‐GAGR …

Polysaccharide-based composite scaffolds for osteochondral and enthesis regeneration

A Baawad, D Jacho, T Hamil… - … Engineering Part B …, 2023 - liebertpub.com
The rotator cuff and Achilles tendons along with the anterior cruciate ligament (ACL) are
frequently injured with limited healing capacity. At the soft-hard tissue interface, enthesis is …