[HTML][HTML] Stat3: linking inflammation to epithelial cancer-more than a" gut" feeling?
A Jarnicki, T Putoczki, M Ernst - Cell division, 2010 - Springer
Inflammation is an important environmental factor that promotes tumourigenesis and the
progression of established cancerous lesions, and recent studies have started to dissect the …
progression of established cancerous lesions, and recent studies have started to dissect the …
[HTML][HTML] Heat shock proteins and hormesis in the diagnosis and treatment of neurodegenerative diseases
Modulation of endogenous cellular defense mechanisms via the vitagene system represents
an innovative approach to therapeutic intervention in diseases causing chronic tissue …
an innovative approach to therapeutic intervention in diseases causing chronic tissue …
[HTML][HTML] Innovative challenge for the inhibition of hepatocellular carcinoma progression by combined targeting of HSP90 and STAT3/HIF-1α signaling
S Saber, EE Abd El-Fattah, AM Abdelhamid… - Biomedicine & …, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is the third foremost cause of cancer-related deaths. HCC
has a very bad prognosis because it is asymptomatic in the early stages, resulting in a late …
has a very bad prognosis because it is asymptomatic in the early stages, resulting in a late …
[HTML][HTML] A novel C-terminal heat shock protein 90 inhibitor that overcomes STAT3-Wnt-β-catenin signaling-mediated drug resistance and adverse effects
Rationale: The heat shock protein (Hsp) system plays important roles in cancer stem cell
(CSC) and non-CSC populations. However, limited efficacy due to drug resistance and …
(CSC) and non-CSC populations. However, limited efficacy due to drug resistance and …
EGFR–PI3K–AKT–mTOR signaling in head and neck squamous cell carcinomas: attractive targets for molecular-oriented therapy
C Freudlsperger, JR Burnett, JA Friedman… - Expert opinion on …, 2011 - Taylor & Francis
Importance of the field: Recent advances in the understanding of the oncogenesis of head
and neck squamous cell carcinomas (HNSCC) have revealed multiple dysregulated …
and neck squamous cell carcinomas (HNSCC) have revealed multiple dysregulated …
[HTML][HTML] HDAC6: a novel histone deacetylase implicated in pulmonary arterial hypertension
O Boucherat, S Chabot, R Paulin, I Trinh… - Scientific reports, 2017 - nature.com
Pulmonary arterial hypertension (PAH) is a vascular remodeling disease with limited
therapeutic options. Although exposed to stressful conditions, pulmonary artery (PA) smooth …
therapeutic options. Although exposed to stressful conditions, pulmonary artery (PA) smooth …
Hsp90 inhibitors and drug resistance in cancer: the potential benefits of combination therapies of Hsp90 inhibitors and other anti-cancer drugs
X Lu, L Xiao, L Wang, DM Ruden - Biochemical pharmacology, 2012 - Elsevier
Hsp90 is a chaperone protein that interacts with client proteins that are known to be in the
cell cycle, signaling and chromatin-remodeling pathways. Hsp90 inhibitors act additively or …
cell cycle, signaling and chromatin-remodeling pathways. Hsp90 inhibitors act additively or …
Cancer stem cells in breast cancer and metastasis
The cancer stem cell theory poses that cancers develop from a subset of malignant cells that
possess stem cell characteristics and has been proposed to account for the development of …
possess stem cell characteristics and has been proposed to account for the development of …
[HTML][HTML] Pimitespib, an HSP90 inhibitor, augments nifuroxazide-induced disruption in the IL-6/STAT3/HIF-1α autocrine loop in rats with bleomycin-challenged lungs …
Idiopathic pulmonary fibrosis is a fatal lung disorder in which the etiology and pathogenesis
are still unobvious. Effective treatments are urgently needed considering that lung …
are still unobvious. Effective treatments are urgently needed considering that lung …
Computational discovery of niclosamide ethanolamine, a repurposed drug candidate that reduces growth of hepatocellular carcinoma cells in vitro and in mice by …
Background & Aims Drug repositioning offers a shorter approval process than new drug
development. We therefore searched large public datasets of drug-induced gene expression …
development. We therefore searched large public datasets of drug-induced gene expression …