[HTML][HTML] Recent applications of fluorescence correlation spectroscopy in live systems
R Macháň, T Wohland - FEBS letters, 2014 - Elsevier
Fluorescence correlation spectroscopy (FCS) is a widely used technique in biophysics and
has helped address many questions in the life sciences. It provides important advantages …
has helped address many questions in the life sciences. It provides important advantages …
Competition for IL-2 between regulatory and effector T cells to chisel immune responses
In this review we discuss how the competition for cytokines between different cells of the
immune system can shape the system wide immune response. We focus on interleukin-2 (IL …
immune system can shape the system wide immune response. We focus on interleukin-2 (IL …
[HTML][HTML] A local regulatory T cell feedback circuit maintains immune homeostasis by pruning self-activated T cells
A fraction of mature T cells can be activated by peripheral self-antigens, potentially eliciting
host autoimmunity. We investigated homeostatic control of self-activated T cells within …
host autoimmunity. We investigated homeostatic control of self-activated T cells within …
[HTML][HTML] A tunable diffusion-consumption mechanism of cytokine propagation enables plasticity in cell-to-cell communication in the immune system
Immune cells communicate by exchanging cytokines to achieve a context-appropriate
response, but the distances over which such communication happens are not known. Here …
response, but the distances over which such communication happens are not known. Here …
[HTML][HTML] Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome
D Kotlarz, N Ziętara, G Uzel, T Weidemann… - The Journal of …, 2013 - ncbi.nlm.nih.gov
Primary immunodeficiencies (PIDs) represent exquisite models for studying mechanisms of
human host defense. In this study, we report on two unrelated kindreds, with two patients …
human host defense. In this study, we report on two unrelated kindreds, with two patients …
Resolving membrane protein–protein interactions in live cells with pulsed interleaved excitation fluorescence cross-correlation spectroscopy
S Christie, X Shi, AW Smith - Accounts of Chemical Research, 2020 - ACS Publications
Conspectus The cell plasma membrane (PM) contains thousands of proteins that sense and
respond to the outside environment. These proteins have evolved sensitivity to a wide …
respond to the outside environment. These proteins have evolved sensitivity to a wide …
Essential role of endocytosis for interleukin-4-receptor-mediated JAK/STAT signalling
K Kurgonaite, H Gandhi, T Kurth… - Journal of cell …, 2015 - journals.biologists.com
Many important signalling cascades operate through specialized signalling endosomes, but
a corresponding mechanism has as yet not been described for hematopoietic cytokine …
a corresponding mechanism has as yet not been described for hematopoietic cytokine …
Multifarious determinants of cytokine receptor signaling specificity
Cytokines play crucial roles in regulating immune homeostasis. Two important
characteristics of most cytokines are pleiotropy, defined as the ability of one cytokine to …
characteristics of most cytokines are pleiotropy, defined as the ability of one cytokine to …
Insights into receptor structure and dynamics at the surface of living cells
F Steiert, P Schultz, S Höfinger, TD Müller… - Nature …, 2023 - nature.com
Evaluating protein structures in living cells remains a challenge. Here, we investigate
Interleukin-4 receptor alpha (IL-4Rα) into which the non-canonical amino acid bicyclo [6.1. 0] …
Interleukin-4 receptor alpha (IL-4Rα) into which the non-canonical amino acid bicyclo [6.1. 0] …
Molecular and cellular factors determining the functional pleiotropy of cytokines
A McFarlane, E Pohler, I Moraga - The FEBS Journal, 2023 - Wiley Online Library
Cytokines are soluble factors vital for mammalian physiology. Cytokines elicit highly
pleiotropic activities, characterized by their ability to induce a wide spectrum of functional …
pleiotropic activities, characterized by their ability to induce a wide spectrum of functional …