Fluorescence correlation spectroscopy (FCS) is a widely used technique in biophysics and
has helped address many questions in the life sciences. It provides important advantages …

In this review we discuss how the competition for cytokines between different cells of the
immune system can shape the system wide immune response. We focus on interleukin-2 (IL …

A fraction of mature T cells can be activated by peripheral self-antigens, potentially eliciting
host autoimmunity. We investigated homeostatic control of self-activated T cells within …

Immune cells communicate by exchanging cytokines to achieve a context-appropriate
response, but the distances over which such communication happens are not known. Here …

Primary immunodeficiencies (PIDs) represent exquisite models for studying mechanisms of
human host defense. In this study, we report on two unrelated kindreds, with two patients …

Conspectus The cell plasma membrane (PM) contains thousands of proteins that sense and
respond to the outside environment. These proteins have evolved sensitivity to a wide …

Many important signalling cascades operate through specialized signalling endosomes, but
a corresponding mechanism has as yet not been described for hematopoietic cytokine …

Cytokines play crucial roles in regulating immune homeostasis. Two important
characteristics of most cytokines are pleiotropy, defined as the ability of one cytokine to …

Evaluating protein structures in living cells remains a challenge. Here, we investigate
Interleukin-4 receptor alpha (IL-4Rα) into which the non-canonical amino acid bicyclo [6.1. 0] …

Cytokines are soluble factors vital for mammalian physiology. Cytokines elicit highly
pleiotropic activities, characterized by their ability to induce a wide spectrum of functional …