Circadian rhythm and sleep disruption: causes, metabolic consequences, and countermeasures
Abstract Circadian (∼ 24-hour) timing systems pervade all kingdoms of life and temporally
optimize behavior and physiology in humans. Relatively recent changes to our …
optimize behavior and physiology in humans. Relatively recent changes to our …
Regulating the suprachiasmatic nucleus (SCN) circadian clockwork: interplay between cell-autonomous and circuit-level mechanisms
ED Herzog, T Hermanstyne… - Cold Spring …, 2017 - cshperspectives.cshlp.org
The suprachiasmatic nucleus (SCN) is the principal circadian clock of the brain, directing
daily cycles of behavior and physiology. SCN neurons contain a cell-autonomous …
daily cycles of behavior and physiology. SCN neurons contain a cell-autonomous …
Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice
The accumulation of adenosine is strongly correlated with the need for sleep and the
detection of sleep pressure is antagonised by caffeine. Caffeine also affects the circadian …
detection of sleep pressure is antagonised by caffeine. Caffeine also affects the circadian …
Photic entrainment of the circadian system
A Ashton, RG Foster, A Jagannath - International journal of molecular …, 2022 - mdpi.com
Circadian rhythms are essential for the survival of all organisms, enabling them to predict
daily changes in the environment and time their behaviour appropriately. The molecular …
daily changes in the environment and time their behaviour appropriately. The molecular …
A Period2 phosphoswitch regulates and temperature compensates circadian period
Period (PER) protein phosphorylation is a critical regulator of circadian period, yet an
integrated understanding of the role and interaction between phosphorylation sites that can …
integrated understanding of the role and interaction between phosphorylation sites that can …
Leptin receptor neurons in the dorsomedial hypothalamus input to the circadian feeding network
Salient cues, such as the rising sun or availability of food, entrain biological clocks for
behavioral adaptation. The mechanisms underlying entrainment to food availability remain …
behavioral adaptation. The mechanisms underlying entrainment to food availability remain …
The cost of circadian desynchrony: evidence, insights and open questions
AC West, DA Bechtold - Bioessays, 2015 - Wiley Online Library
Coordinated daily rhythms are evident in most aspects of our physiology, driven by internal
timing systems known as circadian clocks. Our understanding of how biological clocks are …
timing systems known as circadian clocks. Our understanding of how biological clocks are …
Circadian molecular clock in lung pathophysiology
IK Sundar, H Yao, MT Sellix… - American Journal of …, 2015 - journals.physiology.org
Disrupted daily or circadian rhythms of lung function and inflammatory responses are
common features of chronic airway diseases. At the molecular level these circadian rhythms …
common features of chronic airway diseases. At the molecular level these circadian rhythms …
Multilevel interactions of stress and circadian system: implications for traumatic stress
A Agorastos, NC Nicolaides, VP Bozikas… - Frontiers in …, 2020 - frontiersin.org
The dramatic fluctuations in energy demands by the rhythmic succession of night and day on
our planet has prompted a geophysical evolutionary need for biological temporal …
our planet has prompted a geophysical evolutionary need for biological temporal …
Sleep, circadian system and traumatic stress
A Agorastos, M Olff - European journal of psychotraumatology, 2021 - Taylor & Francis
The human circadian system creates and maintains cellular and systemic rhythmicity
essential for the temporal organization of physiological processes promoting homeostasis …
essential for the temporal organization of physiological processes promoting homeostasis …