Microwave-Assisted Synthesis, Structure, and Preliminary Biological Evaluation of Novel 6-Methoxy-5, 6-dihydro-5-azapurines
We herein disclose the microwave-assisted synthesis of previously unreported 6-methoxy-5,
6-dihydro-5-azapurines, whose purine-like scaffold is promising for drug discovery. The …
6-dihydro-5-azapurines, whose purine-like scaffold is promising for drug discovery. The …
“Dual Anta-Inhibitors” of the A2A Adenosine Receptor and Casein Kinase CK1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies
A Spinaci, M Buccioni, D Catarzi, C Cui, V Colotta… - Pharmaceuticals, 2023 - mdpi.com
Based on a screening of a chemical library of A2A adenosine receptor (AR) antagonists, a
series of di-and tri-substituted adenine derivatives were synthesized and tested for their …
series of di-and tri-substituted adenine derivatives were synthesized and tested for their …
[PDF][PDF] A2A adenosine receptor agonists, antagonists, inverse agonists and partial agonists
Abstract The Gs-coupled A2A adenosine receptor (A2AAR) has been explored extensively
as a pharmaceutical target, which has led to numerous clinical trials. However, only one …
as a pharmaceutical target, which has led to numerous clinical trials. However, only one …
Adenosine A2A Receptor Antagonists: Chemistry, SARs, and Therapeutic Potential
A Spinaci, M Buccioni, C Chang, D Dal Ben… - … Receptors and their …, 2023 - Springer
Many physiological processes are modulated by the naturally occurred nucleoside
adenosine after interaction with four G-protein-coupled receptor subtypes named A1, A2A …
adenosine after interaction with four G-protein-coupled receptor subtypes named A1, A2A …
Sequential, Electrochemical‐Photochemical Synthesis of 1, 2, 4‐Triazolo‐[4, 3‐a] pyrazines
J Yount, M Morris, N Henson, M Zeller… - … A European Journal, 2024 - Wiley Online Library
triazolo‐[4, 3‐a] pyrazine was prepared via a two‐step electrochemical, photochemical
process. First, a 5‐substituted tetrazole is electrochemically coupled to 2, 6 …
process. First, a 5‐substituted tetrazole is electrochemically coupled to 2, 6 …
{\textquotedblleft} Dual Anta-Inhibitors {\textquotedblright} of the A2A Adenosine Receptor and Casein Kinase {CK} 1delta: Synthesis, Biological Evaluation, and …
S Andrea, B Michela, C Daniela, C Chang… - …, 2023 - research.unipd.it
Based on a screening of a chemical library of A2A adenosine receptor (AR) antagonists, a
series of di-and tri-substituted adenine derivatives were synthesized and tested for their …
series of di-and tri-substituted adenine derivatives were synthesized and tested for their …
Triazines, tetrazines and fused ring polyaza systems
P Audebert, V Sol - Progress in Heterocyclic Chemistry, 2024 - Elsevier
This chapter describes broadly the research performed in 2022 on high-nitrogen-content
aromatic heterocycles. It encompasses a section devoted to azines (triazines, tetrazines, and …
aromatic heterocycles. It encompasses a section devoted to azines (triazines, tetrazines, and …